Founded in 2014, Kono Chem Co., Ltd is an export-oriented production enterprise supported by the State Department of Commerce.
Kono Chem covers an area of 312,000 square meters, with scientific and technological personnel accounting for more than 35%. The headquarter of the company is located in Xi'an, Shaanxi Province. It consists of two chemical fermentation workshops, a pilot-scale reaction workshop and a provincial R&D center. Since the establishment of the company, it has been recognized by customers at home and abroad and audited by authoritative laboratories in accordance with ISO9000, ISO14001 and specifications. At present, the company's main products involve biopharmaceuticals, flavors and fragrances, pesticide intermediates, veterinary drug development, and some custom synthesis.

With comprehensive EHS management and high-quality advantages, Kono Chem sells 85% of its products in more than 50 countries around the world, and has established long-term strategic partnerships with multinational companies such as CIPLA, BIOCON, and DSM. The company adheres to the business tenet of "integrity and diligence", with an efficient research and development system, simple and diligent employees, and a responsible corporate culture, and sincerely invites domestic and foreign colleagues who are willing to cooperate for a long time to join the mission for the development of the chemical raw material industry.

Description

Eldecalcitol (Edirol) was approved in January 2011 by the Japanese Ministry of Health, Labor, and Welfare for the treatment of osteoporosis. Because of vitamin D’s central role in the bone health, vitamin D and analogs of vitamin D have been used to treat patients diagnosed with osteoporosis. Eldecalcitol is an analog of the active form of vitamin D, calcitriol, in which the lower cyclohexane ring contains a hydroxypropyl group. The synthesis of eldecalcitol involves the assembly of two units, a fully protected (3S,4S,5R)-oct-1-en-7-yne-3,4,5-triol and a fused bicyclic system, (R)-6- ((1R,3aR,7aR,E)-4-(bromomethylene)-7a-methyloctahydro-1H-inden-1- yl)-2-methylheptan-2-ol, through a Diels-Alder reaction to give fully protected eldecalcitol. The hydroxyl groups are then deprotected to give the parent molecule. Eldecalcitol binds to the vitaminDreceptor 2.7-fold more potently than calcitriol, while only weakly inhibiting serum parathyroid hormone.

Originator

Chugai Pharmaceutical/Roche (Japan)

Uses

Eldecalcitol is a derivative of vitamin D3 (V676045) which is the vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity.

Definition

ChEBI: A hydroxycalciol that is calcitriol with a 3-hydroxypropoxy group at position 2.

brand name

Edirol

Clinical Use

Eldecalcitol is a vitamin D3 analog approved in Japan for the treatment of osteoporosis. Itwasdiscoveredby Chugai and co-developed with Taisho. Eldecalcitol, a hormonally active calcitrol analog, regulates calcium and bone metabolism. The drug was approved on the basis of results from randomized, double-blinded, parallelgroup, phase III studies taking place over three years that showed eldecalcitol to significantly lower incidence of new vertebral fractures compared to those receiving the comparator drug alfacalcidol. Discovery and SAR studies of vitamin D3 analogs leading to the identification of eldecalcitol have been reported. In addition, multiple syntheses, including parallel approaches, have been reported in publications and patents.

Chemical Synthesis

The biomimetic vitamin D3 analog synthesis that was recently disclosed, based on an earlier reported route for the commercial synthesis of alfacalcidol, will be discussed here.
An Oppenauer oxidation converted commercially available cholesterol 141 to enone 142 in 80% yield. A second oxidation event with DDQ provided dienone 143 in 75% yield. Treatment of 143 with sodium ethoxide in ethanol triggered migration of the enone double bond into the B-ring, giving olefin 144 in 53% yield. Stereospecific reduction of ketone 144 with sodium borohydride gave alcohol 145 in 53% yield, which was then immediately protected as the corresponding acetate with acetic anhydride to furnish 146. Next, further dehydrogenation of the B-ring was accomplished using radical bromination of the olefin within 146 through the use of NBS and catalytic AIBN, followed by elimination with collidine. A subsequent saponification step ultimately gave rise to the key diene 147. Next, in order to selectively epoxidize the A-ring olefin, a unique ‘protection’ strategy was employed using phenyl- 1,2,4-triazole-3,5-dione (PTAD). Diels–Alder reaction between diene 147 and PTAD produced cycloadduct 148 in 80% overall yield from acetate 146. Protection of the alcohol as the corresponding TBS ether preceeded a regio- and stereospecific epoxidation with m-CPBA to afford 1,2a-epoxide 150 in 78% yield. Diels–Alder adduct 150 was then subjected to thermal conditions to affect a retro-[ 4+2] reaction to give diene 151. Fluoride-mediated removal of the TBS group prepared 3b-alcohol 152 in 95% yield. Subsequent ring-opening reaction with 1,3-propane diol in the presence of potassium t-butoxide, provided 3-hydroxy propoxy ether 153 in 29% yield. Microbial oxidation of intermediate 153 was accomplished using an Amycolata autotrophica ATCC 33796 culture to obtain eldecalcitol derivative 154 in 64% yield. Subjection of 154 to 400 watt light followed by thermolysis provided eldecalcitol (XII) in 29% yield.