CAS:17321-77-6 Clomipramine hydrochloride factory sales CAS NO.17321-77-6

Min.Order: 1 Kilogram
Payment Terms: L/C,T/T,MoneyGram,Other

Product Details

Keywords

Clomipramine hydrochloride
Clomipramine hydrochloride high purity
3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride

Quick Details

ProName: CAS:17321-77-6 Clomipramine hydrochlo...
CasNo: 17321-77-6
Molecular Formula: C19H23ClN2.HCl
Appearance: powder
Application: Pharmaceutical
DeliveryTime: within 3-4days after received your pay...
PackAge: according to customers' requirements
Port: all chinese port
ProductionCapacity: 100 Kilogram/Week
Purity: 99.5%
Storage: store in cool and dry
Transportation: by sea or by air
LimitNum: 1 Kilogram

Superiority

Description

Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is an ST (serotonin transporter/SERT), SLC6A2 (norepinephrine transporter/NET), and DAT (dopamine transporter) blocker with Ki of 0.14, 54 and 3 nM, respectively. Clomipramine hydrochloride is a tricyclic antidepressant, a norepinephrine-reuptake inhibitor, and an antiobsessional drug.

Clomipramine hydrochloride is an inhibitor of D2 receptor (Ki = 162 nM), D3 receptor (Ki = 30 nM), AR (α1-adrenergic receptor, Ki = 3.2 nM), α2-adrenergic receptor (Ki = 525 nM), H1 receptor (Ki = 31 nM), mACh receptors (Ki = 37 nM), 5-HT2A receptor (Ki = 36 nM), 5-HT2C receptor (Ki = 65 nM), 5-HT3 receptor (Ki = 85 nM), 5-HT6 receptor (Ki = 54 nM), 5-HT7 receptor (Ki = 127 nM), D1 receptor (Ki = 219 nM).

Specification

Items of Test	Limites of Test	Result of Test
Appearance	A white or slightly yellow, crystalline powder.lightly hygroscopic	Meets
Identification	A:Melting point:191-195°C B:IR absorption spectrophotometry C.D.E should comply.	Meets
Appearance of solution	Clear,not more intense than Y5	meets
Solubility	Freely soluble in water and in methlylene chloride,soluble in alcohol	Meets
PH	3.5-5.0	4.2
Sulphated ash	≤0.1%	0.08%
Heavy Metals	≤20ppm	Meets
Loss on drying	≤0.5%	0.31%
Related substances	Impurity B≤1.0% Impurity C.D≤0.2% Impurity F≤0.1% Any impurity ≤0.1% Total of other impurity≤0.2% Total impurities≤1.0%	Meets Meets Meets Meets Meets Meets
Assay(ondried basis)	99.0%-101.0%(USP)	99.15%

Details

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.