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Kono Chem Co.,Ltd

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favourable price of 302-79-4 Tretinoin top quality factory

favourable price of 302-79-4 Tretinoin top quality factory CAS NO.302-79-4

  • FOB Price: USD: 500.00-508.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,MoneyGram,Other
  • Available Specifications:

    Excellent(1-50)KilogramExcellent(50-100)Kilogram

  • Product Details

Keywords

  • favourable price of 302-79-4
  • Tretinoin top quality
  • Tretinoin factory

Quick Details

  • ProName: favourable price of 302-79-4 Tretinoi...
  • CasNo: 302-79-4
  • Molecular Formula: C20H27O2
  • Appearance: solid or liquid
  • Application: for pharma use
  • DeliveryTime: Prompt
  • PackAge: drum and bag
  • Port: Shanghai
  • ProductionCapacity: 5000 Kilogram/Month
  • Purity: 99.90%
  • Storage: in sealed air resistant place
  • Transportation: by sea or air
  • LimitNum: 1 Kilogram
  • Related Substances: NMT0.001%
  • Residue on Ignition: 0.00%
  • Heavy Metal: NMT1ppm
  • Valid Period: 2 years

Superiority

all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid reduces papilloma formation induced by phorbol 12-myristate 13-acetate  in mice. It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis. all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.

Retinoic acid is an endogenous agonist for retinoic acid receptors (IC50 = 14 nM for RARα, RARβ and RARγ receptors). Also promotes differentiation of mouse embryonic stem cells (ESCs) into adipocytes, neurons and glia in vitro. Proposed ligand of RORβ (Kd = 280 nM). Activates autophagy.

Details

Retinoic acid is used in dermatology drugs. It is used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, verrucous epidermal nevus and lichen psoriasis. It is also employed in promoting the proliferation and differentiation of epithelial cells. In addition to this, it exhibits some preventive effect on skin cancer.

 

Alternate Name ATRA; Tretinoin; NSC 122758; Vitamin A Acid; all-trans Retinoic Acid; NSC 122578
Appearance Yellow solid with an orange tinge
CAS # 302-79-4
Molecular Formula C??H??O?
Molecular Weight 300.44
Purity ≥98% by titration
Solubility DMSO (20 mg/ml) or Ethanol (0.5 mg/ml)
SMILES CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
InChi InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChi Key SHGAZHPCJJPHSC-YCNIQYBTSA-N
PubChem CID 444795
MDL Number MFCD00001551
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

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Kono Chem Co.,LtdTel:86-29-86107037-8015 Fax:86-29-81330164  Email:info@konochemical.com
 Address:No.11 Daqing Road,Lianhu District,Xi’an 710082,China,710082