Specification

Chemical and Physical Specifications
Chemical name: Polyhexamethylene biguanide hydrochloride (PHMB)
INCI Name: Polyaminopropyl Biguanide
Other chemical names
Poly(hexamethylenebiguanide hydrochloride)
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), hydrochloride
Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene), hydrochloride
Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride

CAS: 32289-58-0 / 27083-27-8 / 28757-47-3 / 133029-32-0
Molecular formula: (C8H17N5)n.nHCl , n=1-40
Molecular weight> 700 g/mol (submission)
2670 – 2960 (weight average molecular weight)
3686 – 4216 (weight average molecular weight)
HS Code: 2921229000

Physical form:
Off-white to pale yellow powder with strong ammonia smell at 20° C and

101.3 kPa
Very pale yellow to pale yellow, lumpy solid; no obvious odor.
Pale-yellow glass-like solid (technical grade PHMB).
Solubility: soluble in water.
Stability: stable.
Risk: irritation, irritation to skin, eye.
Ecology: May be hazardous to environment. Water body should be given special attention.
Biodegradability: Biodegradable.
Function and uses
PHMB is supported under Directive 98/8/EC for uses as a disinfectant
PHMB is used as a preservative and as an antimicrobial agent. As a preservative, PHMB is
used in cosmetics, personal care products, fabric softeners, contact lens solutions, hand
washes, and more.

In cosmetics, PHMB is used as a broad spectrum preservative. It is freely water soluble and therefore widely used in water-based products which are most susceptible tomicroorganism growth. It has an excellent activity against a wide range of Gram positive and Gram negative bacteria, fungi and yeasts and is particularly effective against microorganisms such as Pseudomanas species, which are difficult to control.

PHMB is also used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and trays, farm equipment, animal drinking water, and hard surfaces for food handling institutions and hospitals; and to deodorize vacuums and toilets. PHMB is used in antimicrobial hand washes and rubs and air filter treatments as an alternative to ozone.

PHMB is also used as an active ingredient for recreational water treatment, as a chlorinefree polymeric sanitizer, which is effective against a wide variety of microorganisms.

Further reported uses of PHMB are purification of swimming pool water, beer glass sanitisation, solid surface disinfection in breweries and short-term preservation of hides and skins.

Application :
It is an antiseptic and bactericide. This is broad-spectrum antibacterial fugicide, take effective for kill gram-positive bacteria, gram-negative bacteria, fungus and yeast; usually used for swimming pool bactericide, universal detergent and disinfector as a fugicide.Compare with PHMG, it has a better bacteriostasis effect for Aspartate bacillis, beer yeast and Aspergillus niger than PHMG.

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries. 

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis. 

With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry. 

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.