CAS:50--02--2 Dexamethasone CAS NO.50-02-2

Min.Order: 1 Kilogram
Payment Terms: T/T,MoneyGram,Other

Product Details

Keywords

Dexamethasone
Dexamethasone high purity
9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione

Quick Details

ProName: CAS:50--02--2 Dexamethasone
CasNo: 50-02-2
Molecular Formula: 9alpha-Fluoro-11beta,17alpha,21-trihyd...
Appearance: White powder
Application: Medicine
DeliveryTime: within 3-4days after received your pay...
PackAge: according to customers' requirements
Port: all chinese port
ProductionCapacity: 100 Kilogram/Month
Purity: 99.5%
Storage: store in cool and dry
Transportation: by sea or by air
LimitNum: 1 Kilogram

Superiority

Dexamethasone

Specification

ITEMS	STANDARD	RESULTS
Characteristics	A White or practically white, odorless, crystalline powder	Conforms
Specific rotation	75° (c=1, dioxane)	75°
Purity	98% to 99.9%	99.2%
Identification	A. IR	Conforms
Identification	B. UV	Conforms
Chromatographic impurity	Total impurities ≤2.0% Any impurities ≤1.0%	conforms
Residue on ignition	≤0.2%	0.1%
Loss on drying	≤0.5%	0.2%
Organic volatile impurities	Meets the requirements	conforms
Particle size	Micronized

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant.

Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils. Dexamethasone is an activator of IDO.

Function

Adrenocorticotropic hormone drugs, anti-inflammatory, anti-allergic and anti-drug more effective than prednisone, and promoting the removal of potassium sodium retention is very light, intramuscular or intravenous pituitary - adrenal strong inhibition:

1. Anti-inflammatory effects: The product can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance. Hormone suppression of inflammatory cells, including leukocytes and macrophages accumulation in sites of inflammation and inhibition of phagocytosis, lysosomal enzyme release and synthesis and release of inflammatory chemical mediators. Can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance.

2. Immunosuppressive effect: preventing or inhibiting cell-mediated immune response, delayed hypersensitivity reactions, reducing T lymphocytes, monocytes, eosinophils, reducing immunoglobulin binding to cell surface receptors and inhibition of the synthesis and release of interleukin, thus reducing the T lymphocyte transformation of lymphoblastoid cells, and reduce the extension of the primary immune response. Can reduce immune complexes through the basement membrane, and can reduce the concentration of ingredients complement and immunoglobulins.

Application

The product is used to treat morning sickness has caused thousands of birth defects Thalidomide (thalidomide) enhanced version, with anti-cancer potential. Compared with thalidomide, fewer adverse reactions, studies have shown that it does not cause birth defects.

Details

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.