NAD⁺, known more formally as nicotinamide adenine dinucleotide, is a signaling molecule as well as a cofactor or substrate for many enzymes. It acts as an oxidizing agent, accepting electrons from other molecules while being converted to its reduced form, NADH NAD⁺ is also essential for the activity of several enzymes, including poly(ADP)-ribose polymerases and cADP-ribose synthases. For example, it is used by some sirtuins to mediate protein deacetylation, producing O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein.

Nadide is a dinucleotide of adenine and nicotinamide. It has coenzyme activity in redox reactions and also acts as a donor of ADP-ribose moieties.

NAD(1-) is an anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, a hydrogen acceptor and a cofactor. It is a conjugate base of a NAD(+).

NAD+, Free Acid is a major electron acceptor molecule in biological oxidation reactions. It is also used as a catalyst intermediate and several enzymes in a multistep system, known as enzyme cycling,.

• Product name

  beta-Nicotinamide adenine dinucleotide (beta-NAD), P2Y₁₁ agonist.

• Description

  Coenzyme and enzyme substrate. P2Y₁₁ agonist.

• Alternative names

  • β-NAD
  • NAD

• Biological description

  Major electron acceptor molecule in biological oxidations. Acts as a coenzyme for hydride-transfer enzymes and a substrate for NAD(+)-consuming enzymes, which include ADP-ribose transferases, poly(ADP-ribose) polymerases, cADP-ribose synthases and sirtuins. Recently reported to be a P2Y₁₁ agonist.

• Purity

  > 95%

• CAS Number

  53-84-9

• Chemical structure