Hot ! Chitosan 9012-76-4 supplier CAS 9012-76-4 Chitosan CAS NO.9012-76-4

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Min.Order: 1 Kilogram
Payment Terms: T/T,MoneyGram,Other
Available Specifications:
EP(1.0000-2000.0000)Kilogram5.0000/Kilogram1.0000USDUSP(1.0000-200.0000)Kilogram10.0000/Kilogram1.0000USDUSP(201.0000-2000.0000)Kilogram5.0000/Kilogram201.0000USD

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Chitosan 9012-76-4 supplier
CAS 9012-76-4 Chitosan
Chitosan CAS 9012-76-4 Powder

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ProName: Hot ! Chitosan 9012-76-4 supplier CAS ...
CasNo: 9012-76-4
Molecular Formula: C9H10O3
Appearance: White fine powder
Application: Pharmaceutical Ingredients
DeliveryTime: 2 Days
PackAge: Drum or Aluminum Foil Bag
Port: ShangHai
ProductionCapacity: 20000 Metric Ton/Month
Purity: 99%MIN
Storage: Cool and dry place
Transportation: prompt delivery after payment confirme...
LimitNum: 1 Kilogram
Grade: Food Grade，Pharma Grade，Other

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Hot ! Chitosan 9012-76-4 supplier CAS 9012-76-4 Chitosan

Antibacterial action of chitosan

Chitosan has a wide range of antibacterial activities, but different concentrations of chitosan have different antibacterial activities. For example, when the concentration of chitosan is 0.1%, the reproduction of all kinds of Fusarium molds can be completely inhibited within 8 days, but the concentration of chitosan has no effect on Rhizopus, Penicillium, Aspergillus and other molds. When the concentration was 0.4%, it had strong inhibitory effect on Escherichia coli, Proteus common, Bacillus subtilis and Staphylococcus aureus. In addition, the antibacterial properties of chitosan with different degrees of deacylation were different, and those with higher degrees of deacylation had stronger anti-mold ability.

One reason is that chitosan interacts with the surface of mold cells, making them more permeable. Chitosan, sodium acetate, adipic acid combined with the antiseptic effect is more obvious, and does not affect the flavor of food.

Antibacterial action of chitosan

There are mainly two mechanisms as follows:

One is that chitosan is adsorbed on the cell surface to form a layer of high molecular membrane, which prevents the transport of nutrients into the cell and thus plays a bactericidal effect.

Another mechanism is that chitosan penetrates into the cell, adsorb the cytoplasm containing anions in the cell, and flocculate to disrupt the normal physiological activities of the cell, thus killing bacteria.

Because the cell wall structure of Gram-positive and Gram-negative bacteria is different, the two effects on them are also different, so different relative molecular weight of chitosan, the antibacterial mechanism is different.

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Chitosan - Medical applications

The main medical applications are:

① to promote blood coagulation and wound healing. Chitosan can promote blood coagulation and can be used as a hemostatic agent. It can also be used for wound filler material, with sterilization, promote wound healing, absorption of wound exudate, not easy to dehydration and contraction, etc.

② as a sustained-release matrix for drugs. Chitosan can be degraded by lysozyme in organisms to produce natural metabolites, which is non-toxic and can be completely absorbed by organisms, so it has great advantages as a drug sustained release agent. Chitosan - based sustained-release drugs are already available in Japan.

③ for artificial tissues and organs. The composite of chitosan and calcium phosphate can be used as bone substitute for bone repair and tooth filling. Composite materials of chitosan derivatives and polyester can be used as artificial blood vessels. Abewidra has developed a new material for treating burns, ulcers and skin infections, called "artificial skin," which acts like natural skin, not only protecting wounds from bacterial infection, but also allowing air and water to permeate through wounds to facilitate healing. Chitosan and chitin can be mixed to make high strength filamentous fibers, used as surgical thread. This kind of surgical thread can be degraded by lysozyme in the organism, and can be fully absorbed by the body without dismantling the wound after healing, and will not produce allergic reaction.

④ It has immunomodulatory activity. Chitosan can activate and mediate a series of biological effects in the body system, and improve the systemic function of phagocytes. Macrophage surface of bacteria polysaccharides receptor, and chitosan as analogues of bacterial polysaccharide, can stimulate macrophage activation, to produce the following response: promote the phagocytosis function, enhance its synergistic effect in other immune response, so as to realize the body of T cell, NK cells and B cells, the regulation of mediated the cellular immune response and the humoral immune response. Therefore, chitosan has immunomodulatory effect on the body.

⑤ Other medical uses. Chitosan gel can be used as a carrier of dental antibiotics, which has the functions of hemostasis, anti-inflammation and wound healing. It can reduce the cholesterol concentration in serum and liver and is used as a cholesterol-lowering agent. Chitosan can strengthen liver function, prevent liver hangover caused by excessive drinking, and has the effect of adsorption and excretion of heavy metals, toxins, pesticides, chemical pigments remaining in the body. When cancer patients take chitosan, it activates immune cells in the body, enabling them to distinguish between normal cells and cancer cells and kill cancer cells. Chitosan can adjust the pH value of the body to weak alkaline, improve the utilization rate of insulin, is beneficial to the prevention and treatment of diabetes. In addition, it also has the function of regulating the endocrine system, making insulin secretion normal, inhibiting the rise of blood sugar and lowering blood lipids.