Xi'an Kono Chem Co., Ltd., founded in 2014, is a holding enterprise of Hongkong Pioneer Biotech Group. It is an export-oriented manufacturing enterprise supported by the Ministry of Commerce. 

Kono Chem is located in Xi'an, Shaanxi Province, equipped with a number of engineers in pharmaceutical, nutrition, bioengineerting, commited themselves to create products that meeet customers' requirements. At present, Kono's main products cover pharmaceutical, food, cosmetics, scientific research. 

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1. Introduction

As its name refers, "spermine" was firstly found in sperm , from where the scientists found not only spermine, but also abundant spermidine. Actually, these two substances exist not only in sperm, they're widely present in other tissues of the human body and in daily food like soybean, wheat germ, mushrooms etc.

Spermidine trihydrochloride is a high purity compound, is much safe and stable than spermidine, and is suitable for making dietary supplement. Kono Chemical can supply different forms of spermidine related products from spermine base, spermidine base to wheat germ extract with low purity spermidine.

2. Main Functions

The main functions of spermidine trihydrochloride are anti-aging and prolong life.

Scientific studies have confirmed that spermidine induces significant upregulation of autophagy gene-related transcripts, thereby enhancing autophagy and inhibiting cellular oxidative stress and necrosis. Spermidine supplementation can prolong the lifespan of different experimental animals. Another cross-sectional study in a population from central Italy showed that spermidine and spermine were reduced in whole blood in older adults, but remained at the same high levels in centenarians as in younger individuals.

Although there are many factors that affect people's longevity, at least for now, spermidine and spermine are one of them. An epidemiological study in Asian countries has also shown that the total amount of dietary polyamines is significantly related to the length of human life expectancy in different countries.

Polyamines, which are compounds containing two or more amino groups, are present in almost all cells. Putrescine, spermidine, and spermine are all polyamines involved in a variety of known and unknown biological processes. Spermidine is synthesized from putrescine and serves as a precursor to spermine.

Intracellular spermidine levels depend on how much can be absorbed from the outside of the cell, how much is synthesized endogenously, and how much is catabolized. There are two extracellular sources of spermidine: one is obtained by ingesting food, and the other is produced by intestinal microorganisms; the endogenous biosynthesis of spermidine and spermine requires precursors such as ornithine, the reaction is completed stepwise under the strict control of the relevant enzymes.

Function Mechanism

Human cells will gradually age with age, and some protein structures will become dysfunctional and become garbage. If they are not cleaned up in time, they will not only accelerate aging, but also bring about a series of aging diseases. Spermidine can strengthen autophagy by enhancing cell autophagy. function and maintain gene stability.

Spermidine can induce autophagy through the AKT/AMPK-Fox03-Atg pathway, and can also promote the transport of histone deacetylase 4 (HDAC4) to the nucleus, reduce the content of cytoplasmic HDAC4, and then enhance the micro-organ-related protein 1 1S (microtubule-associated protein 1S, MAP1S) is acetylated and stabilized to activate autophagy. In addition, spermidine can act as an acetyltransferase inhibitor to modulate EP300 activity, thereby altering the acetylation status of Atg5, Atg7, LC3, and Atg12.

3. Applications

Spermidine trihydrochloride can be used in health care and cosmetic products.

4. Flow Chart

5. Quality Standard

6. Method of Analysis

MOA is available upon request.

7. Reference Spectrum