Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

Kaempferol is a naturally occurring flavonoid shown to act as a potent reversible inhibitor of Fatty Acid Synthase. Flavonoids have radical scavenging activity. Studies demonstrate that Kaempferol induces apoptosis in cancer cell lines and PC12 cell research reports Kaempferol to protect against oxidative stress-induced cytotoxicity. Additionally, Kaempferol has been shown to have a neuroprotective effect and represses the advancement of allergic inflammation mediated by IgE in difference cell models. A study which compared the CYP246 activity of Galangin (sc-235240), quercetin (sc-206089), and Kaempferol revealed that Kaempferol was the least potent flavanoid, with quercetin having the highest potency. Kaempferol acts as an inhibitor of Cox-1 activity (IC₅₀ = 180 μM) and inhibits Topo I catalyzed DNA religation in HL-60 cells. Kaempferol is an inhibitor of MAO.

Activates the mitochondrial Ca²⁺ uniporter (EC₅₀ = 7 μM). Induces caspase-9-mediated apoptosis in cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser¹⁰ phosphorylation in mouse epidermal JB6 C141 cells. Activates transcriptional coactivator with PDZ-binding motif (TAZ) and increases osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. Naturally occurring flavonoid found in Gingko biloba and red wine.