Kono Chem Co.,Ltd

Glutathione, Astaxanthin, Resveratrol, Quercetin, Rutin and other APIs

Product Certification

Kono Chem Co.,Ltd

Country:China (Mainland)

Business Type:Other

Assessed supplierAssessed
supplier

qq

    x
  • Mr.Sam
  • Ms.Sarah
  • Mr.Edward

Contacts

  • Mr.Hong
    Tel: 86-29-86107037-8015

  • Mr.Sam
    Tel: 86-29-86107037-8016

  • Ms.Sarah
    Tel: 86-29-86107037-8019

  • Mr.Edward
    Tel: 86-29-86107037-8021

  • Ms.Freya
    Tel: +86 29 86107037-8010

  • Ms.Jessica
    Tel: 029-86107037-8014

  • Mr.Gao
    Tel: +8613289246953

  • Fax: 86-29-81330164
  • URL: http://www.konochem.com
  • Province/state: Shaanxi
  • City: Xi'an
  • Street:No.11 Daqing Road,Lianhu District,Xi’an 710082,China
E-MAIL Supplier    Clike here
Home > Products > 

CAS:540737-29-9 Tofacitinib citrate factory sales

CAS:540737-29-9 Tofacitinib citrate factory sales CAS NO.540737-29-9

  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,Other
  • Product Details

Keywords

  • Tofacitinib citrate
  • Tofacitinib citrate high purity
  • 3-{(3R,4R)-4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl}-3-oxopropanenitrile 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Quick Details

  • ProName: CAS:540737-29-9 Tofacitinib citrate ...
  • CasNo: 540737-29-9
  • Molecular Formula: C22H28N6O8
  • Appearance: White powder
  • Application: Pharmaceutical
  • DeliveryTime: within 3-4days after received your pay...
  • PackAge: according to customers' requirements
  • Port: all chinese port
  • ProductionCapacity: 100 Kilogram/Week
  • Purity: 99.5%
  • Storage: store in cool and dry
  • Transportation: by sea or by air
  • LimitNum: 1 Kilogram

Superiority

 

Tofacitinib citrate Basic information:
Product Name: Tofacitinib citrate
Synonyms: 1-PIPERIDINEPROPANENITRILE, 4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN

-4-YLAMINO)-BETA-OXO-, (3R,4R)-, 2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE (1:1);1-

Piperidinepropanenitrile, 4-Methyl-3-(Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMino)-

β-oxo-, (3R,4R)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);Tofacitinib citrate

(CP-690550);Tofacitinib citrate;Tasocitinib citrate;Tasocitinib citric acid

s...;Xeljanz;CP-690550 (Tofacitinib citrate)
CAS: 540737-29-9
MF: C16H20N6O.C6H8O7
MW: 504.497
Product Categories: Inhibitor

 

Description:
 Tofacitinib (formerly tasocitinib, CP-690550) is a drug being investigated by Pfizer for the treatment of rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease, and other immunological diseases, as well as for the prevention of organ transplant rejection. It is an inhibitor of the enzyme Janus kinase 3 (JAK3), which means that it interferes with the JAK-STAT signaling pathway that transmits information outside the cell into the cell nucleus, influencing DNA transcription. Recently it has been shown in a murine model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3.

 

Packaage: 50g 500g 1kg in a Al foil bag & 25kg/barrel. 2. The packaging can be customised.

 

Storage: In cool, dry container, avoid heat and light.

 

 

Product Name
Tofacitinib citrate
CAS No.
540737-29-9
Molecular Formula
C16H20N6O.C6H8O7
Batch No.
HR2016082001
TEST
SPECIFICATION
RESULT
Appearance
White to Off-white powder
White powder
Identification
1-HNMR: Consistent with the standard
Conforms
HPLC: The HPLC spectrum of the sample must be concordant with the standard substance.
Conforms
Water
NMT 1.0%
0.26%
ignition residue
NMT 0.1%
Conforms
Heavy Metals
Total: NMT 10ppm
Conforms
Palladium: NMT 1ppm
Conforms
Melting Point
198-201℃
198-200℃
Related Substance
Any other impurity: NMT 0.1%
0.06%
Total impurities: NMT 0.5%
0.11%
Enantiomer: NMT 0.5%
0.04%
Residual Solvents
Ethanol: NMT 0.5%
Conforms
N-Heptane: NMT 0.5%
Conforms
Toluene: NMT 0.089%
Conforms
Citric acid: 37%-39%
38.2%
Assay(By HPLC)
98.0%~102.0%
99.68%
Storage
Store in a tightly closed container in a cool and dry place, below 20℃.
Conclusion
Confirm to enterprise standard

 

Details

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries. 

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis. 

With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry. 

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.

 

 

 

 

  • Jessica   :

 

 

 

Other products of this supplier

Kono Chem Co.,LtdTel:86-29-86107037-8015 Fax:86-29-81330164  Email:info@konochemical.com
 Address:No.11 Daqing Road,Lianhu District,Xi’an 710082,China,710082