CAS:941678-49-5 Ruxolitinib CAS NO.941678-49-5

Min.Order: 1 Kilogram
Payment Terms: T/T,Other

Product Details

Keywords

Ruxolitinib
Ruxolitinib high purity
(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Quick Details

ProName: CAS:941678-49-5 Ruxolitinib
CasNo: 941678-49-5
Molecular Formula: C17H18N6
Appearance: White powder
Application: Pharmaceutical
DeliveryTime: within 3-4days after received your pay...
PackAge: according to customers' requirements
Port: all chinese port
ProductionCapacity: 100 Kilogram/Week
Purity: 99.5%
Storage: store in cool and dry
Transportation: by sea or by air
LimitNum: 1 Kilogram

Superiority

Description

Ruxolitinib (INCB018424) is a JAK inhibitor of JAK1 (IC50 = 2.7 nM), JAK2 (IC50 = 4.5 nM), and JAK3 (IC50 = 322 nM). JAKs, or

Janus-associated kinases, are tyrosine kinases found in the cytoplasm that are known to active the signaling of certain growth

factor receptors and cytokines.

Specification

Analysis Test

Specification

Result

Description

White to off-white crystalline powder,odorless

Conforms

Solubility

Easily soluble in water, unsoluble in ethanol

Conforms

6.0~7.5

6.9

Solution clarity and color

solution should be clear and colorless

Conforms

Related substances

5’CMP 0.3%

Simple impurity

Total other impurity

0.01%

0.03%

0.10%

Chloride

0.05%

Conforms

Ammonium

0.05%

Conforms

0.01%

Conforms

Phosphate

0.1%

Conforms

Loss on drying

≤6.0%

1.3%

Heavy metals

0.002%

Conforms

Arsenide

0.0001%

Conforms

Bacterial Endotoxins

0.3EU/mg

Conforms

Microbial Limit

Conforms

Assay(on dried basis)

≥98.0%

98.8%

Conclusion: The results conform with CP2010

Details

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.