Naturally occurring (-)-form is a major biosynthetic precursor of phenylalanine, tyrosine, and tryptophan and hence of the majority of plant alkaloids. It is also involved in the biosynthesis of lignin, flavonpids and other important aromatic compounds.

Shikimic acid Usage：

1. It is an anti-tumor drug and also a synthetic raw material for anti-tumor drugs such as dioxamycin and glyoxalase inhibitors

2. Shikimic acid is used as the starting material of oseltamivir (the active ingredient of Tamiflu), which is a neuraminidase inhibitor and can be used to treat and prevent influenza A and influenza B 

Shikimic acid Packaging and Shipping：

25kg/drum

Shikimic acid Storage:

Stored in a dry and ventilated warehouse; keep away from sunshine; avoid fire; avoid moisture.

1.Illicium Verum Extract/ Anise Extract Shikimic acid effected by arachidonic acid.
2.Illicium Verum Extract/ Anise Extract Shikimic acid acts as anti-inflammatory ,analgesic.
3.Illicium Verum Extract/ Anise Extract Shikimic acid is the drug intermediates of anti-cancer and anti-virus.
4.Moreover, Illicium Verum Extract/ Anise Extract shikimic acid is also the basis raw materials of combating avian flu.
5.Illicium Verum Extract/ Anise Extract Shikimic acid can inhibit the concentrating of the blood platelets,inhibit arterial,venous
thrombosis and cerebral thrombosis.
6. Illicium Verum Extract/ Anise Extract shikimic acid also as antiviral and anticancer medicine intermediates.

Reputable Manufacturer Supply Hot Sale 138-59-0 with Efficient Delivery

• Molecular Formula:C7H10O5
• Molecular Weight:174.153
• Appearance/Colour:white solid 
• Vapor Pressure:4.45E-08mmHg at 25°C 
• Melting Point:185-187 ºC 
• Refractive Index:-180 ° (C=1, H2O) 
• Boiling Point:400.5 ºC at 760 mmHg 
• PKA:pK (14.1°) 5.19 
• Flash Point:210.1 ºC 
• PSA：97.99000 
• Density:1.725 g/cm³ 
• LogP:-1.51620 

Shikimic acid(Cas 138-59-0) Usage

Definition	ChEBI: A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and micro rganisms.
Biochem/physiol Actions	Shikimic acid is observed to be carcinogenic in rat models, when administered. It serves as a precursor for the biosynthesis of aromatic amino acids, alkaloids and other aromatic metabolites in microorganisms. Shikimic acid is known to inhibit adenosine diphosphate (ADP) induced platelet aggregation and blood coagulation in rabbits.

InChI:InChI=1/C7H10O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1,4-6,8-10H,2H2,(H,11,12)/p-1/t4-,5-,6-/m1/s1

138-59-0 Relevant articles

Enantiospecific synthesis of (-)-5-epi-shikimic acid and (-)-shikimic acid

Jiang, Shende,McCullough, Kevin J.,Mekki, Boualem,Singh, Gurdial,Wightman, Richard H.

, p. 1805 - 1814 (1997)

Diastereoselective reaction of 2,3-O-iso...

Chemical and toxicological studies on bracken fern, Pteridium aquilinum var. latiusculum. VI. Isolation of 5-O-caffeoylshikimic acid as an antithiamine factor

Fukuoka

, p. 3219 - 3224 (1982)

5-O-Caffeoylshikimic acid (dactylifric a...

Shikimic acid and quinic acid: Replacing isolation from plant sources with recombinant microbial biocatalysis [4]

Draths,Knop, David R.,Frost

, p. 1603 - 1604 (1999)

-

Hydroaromatic equilibration during biosynthesis of shikimic acid

Knop,Draths,Chandran,Barker,Von Daeniken,Weber,Frost

, p. 10173 - 10182 (2001)

The expense and limited availability of ...

Stereochemistry of chorismic acid biosynthesis.

Hill,Newkome

, p. 5893 - 5894 (1969)

-

Synthesis of aminoshikimic acid

Guo, Jiantao,Frost

, p. 1585 - 1588 (2004)

5-Amino-5-deoxyshikimic acid (aminoshiki...

An enantioconvergent route to (-)-shikimic acid via a palladium-mediated elimination reaction

Yoshida, Naoyuki,Ogasawara, Kunio

, p. 1461 - 1463 (2000)

(Matrix presented) (-)-Shikimic acid, th...

Enantiospecific synthesis of (-)-5-epi-shikimic acid and a new route to (-)-shikimic acid

Jiang, Shende,Mekki, Boualem,Singh, Gurdial,Wightman, Richard H.

, p. 5505 - 5508 (1994)

(-)-Shikimic acid (1) and (-)-5-epi-shik...

New phenolic compounds from Meehania urticifolia

Murata, Toshihiro,Miyase, Toshio,Yoshizaki, Fumihiko

, p. 385 - 390 (2011)

A new phenylethanoid glycoside, rashomos...

Stereodivergent Syntheses of All Stereoisomers of (?)-Shikimic Acid: Development of a Chiral Pool for the Diverse Polyhydroxy-cyclohexenoid (or -cyclohexanoid) Bioactive Molecules

He, Yun-Gang,Huang, Yong-Kang,Xu, Zhang-Li,Xie, Wen-Jing,Luo, Yong-Qiang,Li, Feng-Lei,Zhu, Xing-Liang,Shi, Xiao-Xin

, p. 4318 - 4332 (2021/07/21)

Novel stereodivergent total syntheses of...

A C 2-symmetric chiral pool-based flexible strategy: Synthesis of (+)- and (-)-shikimic acids, (+)- and (-)-4- epi -shikimic acids, and (+)- and (-)-pinitol

Ananthan, Bakthavachalam,Chang, Wan-Chun,Lin, Jhe-Sain,Li, Pin-Hui,Yan, Tu-Hsin

, p. 2898 - 2905 (2014/05/06)

Via combination of a novel acid-promoted...

A concise route to (-)-shikimic acid and (-)-5-epi-shikimic acid, and their enantiomers via Barbier reaction and ring-closing metathesis

Kancharla, Pavan K.,Doddi, Venkata Ramana,Kokatla, Hariprasad,Vankar, Yashwant D.

scheme or table, p. 6951 - 6954 (2010/02/28)

A simple route for the synthesis of natu...

138-59-0 Process route

73263-62-4

5-trans-caffeoylshikimic acid

331-39-5,501-16-6

caffeic acid

138-59-0

shikimic acid

Conditions

Conditions	Yield
In hydrogenchloride; reflux 30 min, room temp. overnight;

2280-44-6

D-Glucose

138-08-9

phosphoenolpyruvic acid

138-59-0

shikimic acid

77-95-2

D-(-)-quinic acid

2922-42-1

(-)-3-dehydroshikimic acid

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; E. coli SP1.1; pKD12138; citric acid; In water; at 33 ℃; pH=7.0; Further Variations:; Reagents; Enzyme kinetics;

138-59-0 Upstream products

• 
  50-99-7

  D-glucose

• 
  90927-40-5

  3a,6,7,7a-tetrahydro-7-hydroxy-2,2-dimethyl-[3aR-(3aα,7α,7aα)]-1,3-benzodioxole-5-carboxylic acid

• 
  40983-58-2

  methyl shikimate

• 
  2922-42-1

  (-)-3-dehydroshikimic acid

138-59-0 Downstream products

• 
  271-44-3

  benzimidazole

• 
  40983-58-2

  methyl shikimate

• 
  65-85-0

  benzoic acid

• 
  4521-88-4

  (-)-dihydroshikimic acid