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 The superior product quality is guaranteed by 300,000 level airconditioning clear system within purification, drying and packing procedures. We have 2 sales departments over 30 people and sell our products all over the world.

We also have strong professional research and development team, talented personnel and completely equipped laboratory for the quality controlling. Various Detection Device is equipped inKono, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

Why choose us

1.Free sample and Unconditional assume response
2.100% Natural product, without any synthesize ingredient
3.Manufacturer direct supply, provide OEM, R&D service   
4.Competitive price
5.Fast delivery by DHL,TNT,EMS,FEDEX,as your requirement.

 The superior product quality is guaranteed by 300,000 level airconditioning clear system within purification, drying and packing procedures. We have 2 sales departments over 30 people and sell our products all over the world.

We also have strong professional research and development team, talented personnel and completely equipped laboratory for the quality controlling. Various Detection Device is equipped inKono, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

Why choose us

1.Free sample and Unconditional assume response
2.100% Natural product, without any synthesize ingredient
3.Manufacturer direct supply, provide OEM, R&D service   
4.Competitive price
5.Fast delivery by DHL,TNT,EMS,FEDEX,as your requirement.

Best quality nootropics 98% noopept powder

Other name: N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester

CAS: 157115-85-0

Molecular Formula: C17H22N2O4

Molecular Weight: 318.37

Assay: 98.0~101.0%

Appearance: White powder with characteristic odor

 1.Specification

2.About Noopept

Noopept, a strong cognitive enhancer, was developed in Russia in the early 2000s for the treatment of alcohol induced brain damage.  

A mind-turning supplement, Noopept is a powerful substance which is able to cross the blood brain barrier. It works primarily by binding to glutamate receptors and exerting strong neuroprotective effects on the brain. Its high bio-availability also means it is fast acting and may have a cumulative effect. 

While it is most well known as a brain supplement, Noopept also increases coordination and improves mood. It is able to help fight fatigue and avoid caffeine withdrawals with no noticeable side effects. It makes a great study aid, since it will not cause insomnia.

Some research also indicates that this supplement may help to prevent oxidization damage to the brain. It also works to treat alcohol related brain damage (this was actually the original purpose for its development).   

 3.Benefits

· Increases coordination

· Improves mood

· Helps fight fatigue

· Prevents oxidation within the brain

· Treats alcohol related brain damage

· Prevents caffeine withdrawal symptoms
4.Scientific Studies
In one of the most well known Russian studies, the effects of noopept supplementation was studied on the rat brain. This included both single and long term (28 days) treatment. Some of the conclusions reached regarding the long term treatment include: 

Long term treatment did NOT result in the development of tolerance

The changes caused by the nootropic supplement may play a role in neural restoration

Neurotrophin synthesis in the hippocampus (which the supplement clearly increased) determines cognitive function, especially delayed memory retrieval

Noopept holds much promise to prevent the development of Alzheimer's in patients with mild cognitive impairment
5.Dosage
Suggested dosage is 10-30mg daily.   

Volumetric measuring devices cannot be used to accurately measure a supplement powder. Due to the potency and nature of this product, you MUST use a scale with resolution of at least 1 milligram (0.001 grams) which you can find in our store.

6.Synergistic Stacks
Noopept works well in combination with other Nootropic supplements such as Choline CDP, and Vinpocetine.

Trustworthy Factory Supply Reliable Quality 157115-85-0 Nootropics with Efficient Shipping

• Molecular Formula:C17H22N2O4
• Molecular Weight:318.373
• Appearance/Colour:white powder 
• Vapor Pressure:4.93E-12mmHg at 25°C 
• Melting Point:94.0 to 98.0 °C 
• Refractive Index:1.548 
• Boiling Point:547.3°Cat760mmHg 
• PKA:13.41±0.20(Predicted) 
• Flash Point:284.8°C 
• PSA：75.71000 
• Density:1.202g/cm³ 
• LogP:1.22820 

ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate(Cas 157115-85-0) Usage

History	Noopept (previously GVS-111) is a nootropic developed at the Zakusov Institute of Pharmacology (Russian Academy of Medical Sciences) by T. A. Gudasheva. It is one of several nootropics developed based on the structure of piracetam. Its advantage over piracetam is that it can be taken at a lower dose.Noopept is a popular cognitive-enhancing supplement in the nootropic community. Proposed mechanism of actions based on preclinical studies include increasing acetylcholine signaling, increasing the expression of BDNF and NGF, protecting from glutamate toxicity, and increasing inhibitory neurotransmission in the brain.www.alzdiscovery.org
Biochem/physiol Actions	Noopept is a nootropic and neuroprotective drug that normalizes the balance of the pro- and antioxidant systems. Noopept modulates a variety of physiological functions including cognition and anxiety. Noopept significantly weakens streptozotocin-Induced diabetes in rats.
Side effects	Noopept is associated with some mild side effects based on limited clinical evidence. possible side effects of noopept included sleep disturbances (5/31 patients), irritability (3/31), and increased blood pressure (7/31) (Neznamov and Teleshova, 2009).
Preparation	Noopept (ethyl ester of N-phenylacetyl-L-prolylglycine) was designed as a drug at State Zakusov Institute of Pharmacology. The synthesis of the drug is based on the original hypothesis of peptide design, according to which structures similar to known psychotropic agents are reproduced using appropriate amino acids. The non-peptide prototype of Noopept is the nootropic drug Piracetam.1. Perform the carboxylation of N-phenylacetyl-L-proline and ethyl glycine in the presence of isobutyl chloroformate. 2. Add slowly isobutyl chloroformate (1.17 g, 8.6 mmol) to a solution of N-phenylacetyl-L-proline (2.0 g, 8.6 mmol) dissolved in a mixed solvent of THF and dichloromethane (1:1; THF/dichloromethane (v/v)).3.Stir the mixture for 4 h at 0 ～5 °CMolecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept

InChI:InChI=1/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1

157115-85-0 Relevant articles

Synthesis and antiamnesic activity of a series of N-acylprolyl-containing dipeptides

Gudasheva,Voronina,Ostrovskaya,Rozantsev,Vasilevich,Trofimov,Kravchenko,Skoldinov,Seredenin

, p. 151 - 157 (2007/10/03)

Eaters and amides of a series of N-acylp...

157115-85-0 Process route

623-33-6

glycine ethyl ester hydrochloride

C₁₈H₂₃NO₄

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; In chloroform; N,N-dimethyl-formamide; at -5 - 20 ℃; for 1.5h; Yield given;

2752-38-7

(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C 2: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C With 4-methyl-morpholine; In chloroform; N,N-dimethyl-formamide;

157115-85-0 Upstream products

• 
  623-33-6

  glycine ethyl ester hydrochloride

• 
  2752-38-7

  (S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

• 
  103-80-0

  phenylacetyl chloride

• 
  147-85-3

  L-proline

157115-85-0 Downstream products

• 
  157115-95-2

  N-phenylacetyl-L-prolylglycine