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High quality Tadalafil 99% CAS 171596-29-5 with lower price

High quality Tadalafil 99% CAS 171596-29-5 with lower price CAS NO.171596-29-5

  • FOB Price: USD: 400.00-450.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,T/T,Other
  • Available Specifications:

    TOP (1-25)KilogramTOP (25-50)Kilogram

  • Product Details

Keywords

  • Tadalafil
  • 171596-29-5
  • Tadalafil 99%

Quick Details

  • ProName: High quality Tadalafil 99% CAS 171596-...
  • CasNo: 171596-29-5
  • Molecular Formula: C22H19N3O4
  • Appearance: Solid powder
  • Application: Cialis (or Tadalafil) was developed by...
  • DeliveryTime: Prompt
  • PackAge: drum and bag
  • Port: Beijing or Guangzhou
  • ProductionCapacity: 3000 Kilogram/Month
  • Purity: 99.90%
  • Storage: in sealed air resistant place
  • Transportation: by sea or air
  • LimitNum: 1 Kilogram
  • Related Substances: NMT0.001%
  • Residue on Ignition: 0.00%
  • Heavy Metal: NMT1ppm
  • Valid Period: 2 years
  • Product name: Tadalafil
  • CAS: 171596-29-5
  • Purity: 99%

Superiority

Product Name: Tadalafil
Synonyms: TADALAFIL;CIALIS;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;Cialis(IC351)
CAS: 171596-29-5
MF: C22H19N3O4
MW: 389.4
EINECS: 200-835-2
Product Categories: Active Pharmaceutical Ingredients;Cnbio;Erectile Dysfunction;Pyridines ,Halogenated Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Steroid and Hormone;Inhibitor;API;Tadalafil;NUCYNTA
Mol File: 171596-29-5.mol

 

Details

Tadalafil Basic information
Indications and uses Clinical Research Side effects Warnings and precautions
Product Name: Tadalafil
Synonyms: TADALAFIL;CIALIS;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;Cialis(IC351)
CAS: 171596-29-5
MF: C22H19N3O4
MW: 389.4
EINECS: 200-835-2
Product Categories: Active Pharmaceutical Ingredients;Cnbio;Erectile Dysfunction;Pyridines ,Halogenated Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Steroid and Hormone;Inhibitor;API;Tadalafil;NUCYNTA
Mol File: 171596-29-5.mol
Tadalafil Structure
 
Tadalafil Chemical Properties
Melting point  298-300°C
Fp  2℃
storage temp.  Hygroscopic, -20 C Freezer, Under Inert Atmosphere
solubility  DMSO: soluble20mg/mL, clear
color  white to beige
CAS DataBase Reference 171596-29-5(CAS DataBase Reference)
 
Safety Information
Hazard Codes  F,Xn
Risk Statements  11-20/21/22-36
Safety Statements  16-36/37
RIDADR  UN 1648 3 / PGII
RTECS  UQ4431050
Hazardous Substances Data

171596-29-5(Hazardous Substances Data)

 

 

Tadalafil Usage And Synthesis
Indications and uses Cialis (or Tadalafil) was developed by American pharmaceutical company Lilly. It is used to treat erectile dysfunction and belongs to a second generation of PDE5 inhibitors. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours. T1/2 is 17.5h.
Clinical Research In a study of 348 cases of mild to severe erectile dysfunction, patients were randomly given 20mg of Cialis or a placebo. Results showed that in comparison to the placebo group, patients who took Cialis experienced improved intercourse success in the 24-36 hours following medication, with many patients achieving successful sexual intercourse twice in 36 hours. Side effect rate and severity were also no different from those of the placebo group. Over 5% of patients in the Cialis group experienced headaches and indigestion.
Side effects No severe negative reactions. No perceived facial flushing or sight abnormalities following medication. Rare cases of headache and indigestion.
Warnings and precautions Patients currently taking nitrates, experiencing angina pectoris, suffering from heart disease, patients who have unregulated hypertension or hypotension, or patients who have had a stroke in the past 6 months should not take Cialis.
Description Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.
Chemical Properties White to Off-White Cyrstalline Solid
Uses Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor
Uses analgesic, norepinephrine uptake blocker, mu-opiod receptor agonist
Definition ChEBI: A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR
   

 

 

Packaging Details:

25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging   aluminium bag outside and double plastic bag inside                                                                          

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Kono Chem Co.,LtdTel:86-29-86107037-8015 Fax:86-29-81330164  Email:info@konochemical.com
 Address:No.11 Daqing Road,Lianhu District,Xi’an 710082,China,710082