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98% Benfotiamine 22457-89-2 CAS NO.22457-89-2
- FOB Price: USD: 205.00-220.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Available Specifications:
Food grade(1-25)KilogramFood grade(25-50)Kilogram
- Product Details
Keywords
- 22457-89-2
- Benfotiamine
- 98% Benfotiamine
Quick Details
- ProName: 98% Benfotiamine 22457-89-2
- CasNo: 22457-89-2
- Molecular Formula: C22H42N4O8S2
- Appearance: White to off-white powder
- Application: for pharma use
- DeliveryTime: Prompt
- PackAge: drum and bag
- Port: Beijing or Guangzhou
- ProductionCapacity: 1000 Kilogram/Month
- Purity: 50%
- Storage: in sealed air resistant place
- Transportation: by sea or air
- LimitNum: 1 Kilogram
- Related Substances: NMT0.001%
- Residue on Ignition: 0.00%
- Heavy Metal: NMT1ppm
- Valid Period: 2 years
- Product name: Benfotiamine
- Assay: 98%
- Appearance: White to off-white powder
- Type: Vitamin derivatives
- Shelf life: 2 years
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Superiority
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Details
98% Benfotiamine 22457-89-2
Benfotiamine is vitamin B1 fat soluble derivatives, improve the bioavailability of water-soluble vitamin B1 low shortcomings, improve the blood and tissue concentrations of thiamine, so as to improve the curative effect. Benfotiamine is primarily marketed as an antioxidant dietary supplement.
Benfotiamine: N-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide-S-benzoate dihydrogen phosphate
Molecular Structure:
Molecular Formula:C19H23N4O6PS
Molecular Weight:466.45
CAS No.: 22457-89-2
EINECS:245-013-4
Appearance: White crystalline powder
Solubility: insoluble in water
Packing: 25kg/Fibre drum;
Storage:Avoid light, and preserved hermetically.
Certificate of Analysis
|
Test |
Specifications |
Result |
|
Assay |
≥98.0% |
Complies |
|
Appearance |
A white to off-white crystalline powder |
Complies |
|
Identification |
IR |
|
|
Water |
≤ 1.5% |
0.4% |
|
Chloride |
≤0.053% |
0.031% |
|
Sulphate |
≤0.011% |
0.005% |
|
Thiamine |
≤0.1% |
0.06% |
|
Benzoic acid |
Negative |
Complies |
|
Melting point |
≤ 200℃ |
Complies |
|
Heavy metal |
≤ 20ppm |
<10ppm |
|
Conclusion |
Conform with In house Standard |
|
Function&Application
Benfotiamine is useful for the treatment of diabetic retinopathy, neuropathy, and nephropathy however "Most of the effects attributed to benfotiamine are extrapolated from in vitro and animal studies. Unfortunately apparent evidences from human studies are scarce and especially endpoint studies are missing. Therefore additional clinical studies are mandatory to explore the therapeutic potential of benfotiamine in both diabetic and non-diabetic pathological conditions".
It is thought that treatment with benfotiamine leads to increased intracellularthiamine diphosphate levels, a cofactor of transketolase. This enzyme directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway, thus reducing tissue AGEs.
1. Benfotiamine is used for the prevention and treatment of vitamin B1 deficiency;
2. For vitamin B1 demand increase, with inadequate intake from foods supplies (fatigue, hyperthyroidism, pregnancy, lactation, during strenuous manual labor, etc.);
3. Benfotiamine is used in the treatment of non alcoholic wernicke encephalopathy;
4. To treat beriberi;
5. Used in the following diseases, speculation and vitamin B1 deficiency and metabolic disorders associated with treatment, such as: neuralgia; Muscle pain, joint pain; Peripheral neuritis, peripheral nerve palsy; Myocardial metabolic disorders; Constipation and other gastrointestinal motor function obstacle.