Xi'an Kono Chem Co., Ltd., founded in 2014, is a holding enterprise of Hongkong Pioneer Biotech Group. It is an export-oriented manufacturing enterprise supported by the Ministry of Commerce. 

Kono Chem is located in Xi'an, Shaanxi Province, equipped with a number of engineers in pharmaceutical, nutrition, bioengineerting, commited themselves to create products that meeet customers' requirements. At present, Kono's main products cover pharmaceutical, food, cosmetics, scientific research. 

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1. Introduction

Theacrine powder is extracted from Camellia assamica var. kucha, it is also known as 1,3,7,9-tetramethyluric acid, although not as widely known as caffeine or creatine, but as a new pre-workout supplement, it works on both the body and the brain. Its molecular structure is similar to that of caffeine commonly found in tea, except that it has one more methyl group, but just because there is one more methyl group than caffeine, theacrine has completely different physiological functions and health care effects from caffeine.

2. Main Functions

1. Sedative effect

Although the structure of theacrine and caffeine are similar, caffeine has a central stimulant effect, while theacrine has a sedative and hypnotic effect. Some studies have proved that 30 mg/kg mb of theacrine can significantly prolong the sleep time of rats induced by pentobarbital by comparing matrine, caffeine and theobromine;

The hypnotic activity of matrine was further measured, and the pharmacological study of its hypnotic activity was carried out, and it was found that matrine can significantly shorten the sleep latency of rats and prolong the total sleep time of rats. Its hypnotic effect may be related to the regulation of the content of adenosine and adenosine deaminase in rat brain. In addition, when the content of theacrine in bitter tea is more than 3 times the content of caffeine, it can inhibit the central excitatory effect caused by caffeine, and the bitter tea can exhibit sedative and hypnotic effects.

It gives athletes a sense of energy, reduces fatigue, and has a huge positive impact on improving focus and exercise motivation.Theophylline prevents dopamine from being released in the brain and is reabsorbed by the brain, which in turn causes dopamine levels to rise, resulting in sustained mood improvements and greater mental focus.

2. Improve liver adipose and protect liver

Theacrine can improve the liver adipose state of mice by activating its related enzyme pathways, reducing the synthesis of free fatty acids and inhibiting the accumulation of triglycerides in the liver, thereby improving the liver damage caused by high-fat diet in mice; Oxidase activity and gene expression level indirectly scavenge free radicals, thereby ameliorating restraint stress-induced liver injury in mice.

Theacrine powder has a protective effect on the liver of cadmium-injured mice, mainly by scavenging excess free radicals to reduce the degree of oxidative damage to the liver; in addition, it can also increase the activity of antioxidant enzymes (superoxide dismutase and catalase) , enhances the antioxidant capacity of the system as well as anti-inflammatory to synergistically protect the liver.

3. Anti-inflammatory and pain relief

Oral theacrine has good anti-inflammatory effect on ear edema caused by xylene, increased vascular permeability caused by acetic acid and foot swelling caused by carrageenan, and has good anti-inflammatory effect on hot plate test and writhing response caused by acetic acid Pain relief. In addition, theacrine can effectively inhibit the inflammatory response of SD rats induced by incomplete Freund's adjuvant by reducing the level of interleukin-6 in serum and increasing the level of transforming growth factor-β in serum.

3. Applications

Theacrine powder is widely used in healthcare products.

4. Flow Chart

The fruit of Camellia assamica var.kucha→Water extraction→Extraction liquid is extracted with chloroform or dichloromethane→Recovery chloroform or dichloro/alkane→Ethanol solution→Recrystallization→Picrophylline rough spelling→Refining→Finished product

5. Quality Standard

Accoding to Enterprise Standard

6. Method of Analysis

MOA is available upon request.

7. Reference Spectrum