Kono Chem Co.,Ltd

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Kono Chem Co.,Ltd

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CAS:443-48-1 Metronidazole

CAS:443-48-1 Metronidazole CAS NO.443-48-1

  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,Western Union,MoneyGram,Other
  • Product Details

Keywords

  • Metronidazole
  • Metronidazole
  • 2-Methyl-5-nitro-1-imidazoleethanol;

Quick Details

  • ProName: CAS:443-48-1 Metronidazole
  • CasNo: 443-48-1
  • Molecular Formula: C6H9N3O3
  • Appearance: White powder
  • Application: Medicine
  • DeliveryTime: within 3-4days after received your pay...
  • PackAge: according to customers' requirements
  • Port: all chinese port
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 99.5%
  • Storage: store in cool and dry
  • Transportation: by sea or by air
  • LimitNum: 1 Kilogram

Superiority

Name of product:  
Metronidazole         
Expiry Date:
 4 years
ITEMS
STANDARDS
RESULTS
Characteristics
a white or yellowish crystalline powder, slighting sobube in water, in acetone, in alcohol and in methylene, chloride, very slightly solube in ether
COMPLY
Identification
a) Melting point 159-163℃
161.1-161.3℃
b) Specific absorbance 365-395
b) 375
c) IR
c) COMPLY
d) The solution gives the reaction of primary aromatic amines
d) COMPLY
Appearance of solution
SUSPENSION Ⅱ
COMPLY
AND SOLUTION GY6
Related substances
Impurity:0.1MAX
0.02%
Total impurity:0.2MAX
0.06%
Heavy Metal
20PPM MAX
<20PPM
Loss on drying
0.5% MAX
0.19%
Particle size
40-80mesh
COMPLY
Assay
99.0%-101.0%
99.4%

Description of Metronidazole

Pharmacology
In addition to anti-trichomonas and anti-amoeba, in recent years, widely used in anti-anaerobic infections. This product nitro, anaerobic environment in the reduction of amino and anti-anaerobic bacteria show the role of aerobic bacteria or facultative aerobic bacteria is invalid. The following anaerobic bacteria have good antibacterial effect: ① Bacteroides, including Bacteroides fragilis; ② Fusobacterium; ③ Clostridium, including tetanus; ④ partial eubacteria; ⑤ digestive bacteria and digestion Streptococcus and so on. Oral absorption of good (> 80%), oral 250mg or 500mg, 1 ~ 2 hours serum drug concentration peak, respectively 6μg / ml and 12μg / ml. Intravenous infusion of the goods 15mg / kg, after every 6 hours infusion of 7.5mg / kg, plasma drug concentration reached a peak concentration of 25μg / ml, trough concentration of up to 18μg / ml. This product is widely distributed in the body, can enter the saliva, milk, liver abscess pus, can also enter the cerebrospinal fluid (normal CSF concentration of up to 50% of blood). In the body, the side chain oxidation or metabolism with glucuronic acid binding, 20% of the drug is not metabolized. Its metabolites also have a certain activity. Metronidazole and its metabolites by a large number of urinary excretion (60% of the total ~ 80%), a small amount of excretion from the feces (6% ~ 15%). T1 / 2 is about 8 hours.

Indications
Mainly for the treatment or prevention of anaerobic bacteria caused by the system or local infection, such as the abdominal cavity, digestive tract, female genital tract, lower respiratory tract, skin and soft tissue, bone and joint parts of anaerobic infections, sepsis, Membranitis, meningeal infection and the use of antibiotics caused by colitis is also effective. Treatment of tetanus and tetanus antitoxin (TAT) in combination. Can also be used for oral anaerobic infections.

 

Details

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries. 

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis. 

With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry. 

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.

 

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Kono Chem Co.,LtdTel:86-29-86107037-8015 Fax:86-29-81330164  Email:info@konochemical.com
 Address:No.11 Daqing Road,Lianhu District,Xi’an 710082,China,710082