Xi'an Kono Chem Co., Ltd., founded in 2014, is a holding enterprise of Hongkong Pioneer Biotech Group. It is an export-oriented manufacturing enterprise supported by the Ministry of Commerce. 

Kono Chem is located in Xi'an, Shaanxi Province, equipped with a number of engineers in pharmaceutical, nutrition, bioengineerting, commited themselves to create products that meeet customers' requirements. At present, Kono's main products cover pharmaceutical, food, cosmetics, scientific research. 

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1. Introduction

Osthole powder comes from Cnidium Fruit, which mainly exists in Umbelliferae and Rutaceae, and also in a few Compositae and Legumes. Kono Chem has self-control planting base, we can guarantee high quality raw material and stable supply. We can supply different purities from 10% to 98% with different forms. This product is without pesticide residues and low solvent residues. Customized product can also be made upon request.

2. Main functions

2.1. Insecticidal and bacteriostatic efficacy

In addition to the active core structure of coumarin, benzene ring and pyrone ring, osthole also has an important pesticide active gene-isoamylene structure, which shows unique insecticidal and bacteriostatic activity. Studies have shown that osthole is not only effective against cabbage caterpillars, diamondback moths, aphids and other pests and Spodoptera frugiperda egg masses, but also against plant pathogenic fungi such as cucumber powdery mildew, grape downy mildew, pepper Phytophthora, wheat scab, etc. significant inhibitory effect.

Its properties as a biopesticide are as follows:

Slightly toxic and harmless: extremely low toxicity, high safety of application;

Easy to degrade, no residue: This product degrades rapidly in the environment, and has no pollution to the environment;

High-efficiency and broad-spectrum: effectively control powdery mildew of melon, wolfberry, cabbage, lettuce, tobacco, tomato, wheat and strawberry; also have good control effect on aphids;

No drug resistance: Osthole powder has been used for many years, and no drug resistance has been observed.

2.2 Sterilize and relieve itching

According to the theory of traditional Chinese medicine, itching is mainly caused by factors such as wind, heat, dampness, and deficiency of both qi and blood. Cnidium is bitter in taste and has obvious effects of drying dampness and expelling wind.

Experiments have found that osthole can significantly improve both histamine-dependent and histamine-independent pruritus by administering the extract or active ingredients of Cnidium to model animals, but it has an antipruritic effect on histamine-dependent pruritus. Better, its mechanism of action may be related to its inhibition of histamine-induced mast cell degranulation. At the same time, the histamine content in the local skin of the medication was significantly higher than that in the model control group, but the histamine content in the blood was significantly lower than that in the model control group. The above results suggest that Cnidium has a good antipruritic effect on model animals. Osthole and several other plant extracts are formulated together with a strong inhibitory effect on a variety of common Gram-positive and Galanz-negative bacteria, common pathogenic skin fungi, and Pityrosporum that cause dandruff. Shampoo. In addition, a variety of active ingredients act synergistically to block Ca2+ channels and inhibit the release of histamine from mast cells, thereby inhibiting skin itching caused by histamine. It is a mild carrier, safe and low in irritation, and is suitable for skin care products.

3. Applications

Osthole powder has many applications.

A. Used in the field of gynecological antiseptic gel and gynecological lotion

B. It is used in the field of daily chemicals such as lotion, cream, facial cleanser, shampoo, conditioner, shower gel, liquid soap, etc.

C. The field of ointment for anti-inflammatory and itching

D. Used in the field of biological pesticides

① Control cabbage caterpillars. Every 667 square meters, use 80ml to 120ml of 0.4% EC to spray evenly on 50 to 75 liters of water. The effective period is about 7 days, which is safe for crops.

② Control aphids. Use 1% osthole water emulsion 400 times liquid spray to control.

③ Prevention and treatment of powdery mildew of cucumber, pumpkin and strawberry. Use 1% osthole water emulsion 400 times to 500 times to spray and control.

4. Flow Chart

Raw material → Cleaning → Extraction → Concentration → Filtration → Extraction → Crystallization → Drying → Refined powder → Quality Control→ Packaging → Finished product

5. Quality Standard

The product complies with enterprise standard

6. Method of Analysis

MOA is available upon request.

7. Reference Spectrum