Resveratrol is a natural phenylpropanoid of the family of stilbenoids and is present in red wines and certain foods. Resveratrol has been deeply studied for its antioxidant, anti-inflammatory and antimicrobial properties. In Vero cells, resveratrol at 50 μM has shown to have the ability to inhibit SARS-CoV-2 replication by 98% when added after infection. Featured reference paper: Rossi et al, 2021; Yang et al, 2021.

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenol derived from red wine; in Asian folk-medicine Resveratrol and its glycoside,Polydatin (sc-203203) are the primary ingredients of Kojo-Kon (derived from the dried root of Japanese knotweed). Resveratrol, a trihydroxystilbene, is derived from various sources and has been studied with regard to numerous applications including reducing serum lipids, inhibition of platelet aggregation, and actions as a chemopreventative agent and antioxidant. Resveratrol has been shown to increase the longevity of yeast as well as having antiproliferative on cancer stem cells. Resveratrol is a specific inhibitor of Cox-1 (cyclooxygenase-1) via inhibition of the hydroperoxidase activity of Cox-1. Resveratrol has also been used extensively in stem cell studies to enhance self-renewal and multipotency of mesencymal stem cells (MSC′s). Numerous studies have been conducted with regard to Resveratrol-modified cardiac stem cells enhancing cardiac healing. Similar studies with bone marrow derived stem cells (BMSCs) have shown that Resveratrol acts as a NF-κB inhibitor to protect MSC-derived chondrocytes. Additional research with Resveratrol used to treat adipose-derived mesenchymal stem cells (ADMSCs) resulted in increased alkaline phosphatase activity and osteocalcin levels; thus enriching the MSC and osteoprogenitor cell populations in cultured ADMSCs. Resveratrol is also known as Trans-3,4′,5-Trihydroxystilbene, and 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol.

1. Resveratrol can prevent the oxidation of low density lipoprotein, and has the potential effect on preventing cardiovascular disease, cancer, antivirus and immune regulation. Its main role is antioxidant properties.
2. Cardiovascular drugs. It can reduce hematic fat and prevent heart disease. It also has the effect on AIDS.
3. Antioxidants and the activity in anti-inflammatory, antithrombotic, anti-cancer, anti-cancer, anti hyperlipidemia and antibacterial.
4. Anti-aging, regulating blood lipid, cardiovascular protection, anti-hepatitis.
5. Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.