Apigenin 520-36-5  98%MIN  powder

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

Annually, more than 3,000 tons of a wide range of herbal extracts and natural active substances are extracted at the Kono Chem Co.,Ltd manufacturing plant near Xi'an, China. These extracts are in compliance with worldwide GMP、HACCP norms, international Pharmacopoeias, and international regulations.
The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Kono Chem. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

With our phytopharmaceutical background and knowledge through experience, Kono Chem can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.


 

Process Capability :   Suoer critical CO2 extraction method Fermentation expert Other synthesis service

After-sale Service :   Prompt delivery in worldwide 24 hour online Goods return policy

Superiority

pioneerbiotech is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. 

We could give you: 
1.Best quality in your requirement 
2.Competitive price in China market 
3.mature Technical support 
4.Professional logistic support 
All we want is win-win business. Send yr. inquiries, you will get it! 

Specifications

1, free sample
2, prompt delivery
3, long -term stable supply
4, 8 years experence in the plant extract.

Reputable Factory Supply Quality 520-36-5 In Bulk Supply

• Molecular Formula:C15H10O5
• Molecular Weight:270.241
• Appearance/Colour:Pale Yellow Crystalline Solid 
• Vapor Pressure:6E-13mmHg at 25°C 
• Melting Point:345-350 °C 
• Refractive Index:1.732 
• Boiling Point:555.5 °C at 760 mmHg 
• PKA:6.53±0.40(Predicted) 
• Flash Point:217 °C 
• PSA：90.90000 
• Density:1.548 g/cm³ 
• LogP:2.57680 

Apigenin(Cas 520-36-5) Usage

Preparation	4-hydroxybenzaldehyde (1.22 g, 9.97 mmol, 1.0 equiv) was added to asolution of 50% KOH (aq.) (6.72 g, 59.82 mmol, 6.0 equiv) and ethanol (3 mL) andstirred for 10 min. Then compound 9 (2.02g, 9.97 mmol, 1.0 equiv) was added to the reaction mixture and heated to 60 °C and stirred for 4 h. After cooled toroom temperature, the mixture was poured into ice water and acidified withconcentrated hydrochloric acid to pH = 3. Then the suspension was filtrated, washed and the residue was dried toafford Apigenin(2.43 g, 90%) as a red solid.
Anticancer Research	It induces apoptosis by targeting leptin/leptin receptor pathway and by targeting caspase-dependent extrinsic pathway aswell as STAT3 signaling pathway in lung adenocarcinoma and BT-474 breast cancercells, respectively. It shows antitumor activity against breastcancer MCF-7 cells and colon cancer HCT 116 cells and is a mediator of cancerchemoprevention and an inducer of autophagy. It can be used to treat colon canceras it induces apoptosis in colon cancer cells. It also increase melanogenesis in B16cells by activating the p38 MAPK pathway.
Purification Methods	The current method for the purification of apigenin is crude-solvent extraction method by using solvent in small quantity and also time saving. Apigenin that was isolated from Symphyotrichum novae-angliae was obtained in large quantity and directly from extract.

InChI:InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

520-36-5 Relevant articles

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Dranik

, (1970)

-

Biotransformation of chrysin and apigenin by Cunninghamella elegans

Ibrahim, Abdel-Rahim Sayed

, p. 671 - 673 (2005)

Biotransformation of chrysin by Cunningh...

Regioselective ortho-Hydroxylations of Flavonoids by Yeast

Sordon, Sandra,Madej, Anna,Pop?oński, Jaros?aw,Bartmańska, Agnieszka,Tronina, Tomasz,Brzezowska, Ewa,Juszczyk, Piotr,Huszcza, Ewa

, p. 5525 - 5530 (2016)

Natural flavonoids, such as naringenin, ...

New Flavonoid Glycoside from Thalictrum minus

Komilov,Agzamova,Isaev,Eshbakova

, (2020)

The new flavonoid diglycoside thamiflasi...

Secondary metabolites of an Algerian Phlomis bovei and their antioxidant activities

Zaabat,Akkal,Darboure,Laouer,Franca, M. G. Dijoux,Duddeck, Helmut

, p. 454 - 455 (2010)

-

A new flavonoid glycoside from the leaf of Cephalotaxus koreana

Bae, KiHwan,Jin, WenYi,Thuong, Phuong Thien,Min, Byung Sun,Na, MinKyun,Lee, Young Mi,Kang, Sam Sik

, p. 409 - 413 (2007)

A new flavone glycoside, apigenin 5-O-α-...

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Gusev et al.

, (1977)

-

Cloning of parsley flavone synthase I

Martens, Stefan,Forkmann, Gert,Matern, Ulrich,Lukacin, Richard

, p. 43 - 46 (2001)

A cDNA encoding flavone synthase I was a...

FLAVONOID GLYCOSIDES OF ARTEMISIA MONOSPERMA AND A. HERBA-ALBA

Saleh, Nabiel A. M.,El-Negoumy, Sabry I.,Abd-Alla, Mohamed F.,Abou-Zaid, Mamdouh M.,Dellamonica, G.,Chopin, J.

, p. 201 - 203 (1985)

Ten flavonoid glycosides were isolated a...

-

Zykova,Pivenko

, (1975)

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A NEW GLYCOSYLATED FLAVONOID, 7-O-α-L-RHAMNOPYRANOSYL-4'-O-RUTINOSYLAPIGENIN, IN THE EXUDATE FROM GERMINATING SEEDS OF Sesbania rostrata

Messems, Eric,Montagu, Marc Van,Bruyn, Andre De,Jans, Arnold W. H.

, p. 241 - 254 (1989)

The title apigenin triglycoside was isol...

COSMETIC COMPOSITION FOR SKIN IMPROVEMENT COMPRISING GREEN BARLEY EXTRACT

-

, (2022/02/05)

Provided is a cosmetic composition for s...

Studies on Bignoniaceae: Newbouldiosides D-F, Minor Phenylethanoid Glycosides from Newbouldia laevis, and New Flavonoids from Markhamia zanzibarica and Spathodea campanulata

Kolodziej, Herbert

, p. 989 - 997 (2020/11/18)

Continued examination of the stem bark o...

Continuous flow microchannel synthesis process of flavonoid compounds

-

Paragraph 0050-0060, (2021/06/22)

The invention provides a continuous flow...

Extraction, Isolation and Characterization of Valuable Worked on Acacia Tortilis

Muhaisen, Hasan M. H.

, p. 6731 - 6747 (2021/11/01)

Acacia tortilis is one of the important ...

520-36-5 Process route

apigenin-7-O-(β-D-apiofuranosyl-(1→2)-α-L-rhamnopyranozide)

639-97-4,6477-44-7,42927-70-8

D-apiose

3615-41-6,478518-52-4

L-Rhamnose

520-36-5

5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With hydrogenchloride; In methanol; for 2h; Reflux;	2.5 mg

480-41-1

5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-on

520-36-5

5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

4049-38-1

eriodictyol

Conditions

Conditions	Yield
With plasmid pFusionF87V-carrying recombinant Escherichia coli BL21 (DE3) cells; at 28 ℃; for 24h; Microbiological reaction;	5.2% 3.7%

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