High quality raw material Indomethacin

Description:

Indomethacin 
CAS No.: 53-86-1 
MF: C19H15ClNO4 
EINECS No.: 200-186-5

Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. Other studies show indomethacin to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes, which could consequentially effect plasma membrane assembled cell signaling cascades. Indomethacin is an activator of PPAR α.

Function and usage

This product has obvious effect on anti-inflammation and antipyretic, can be easily absorbed and excreted. It can be fully absorbed after taken orally in the gastrointestinal tract,  and in 1-4 hours the  plasma concentration will reach a peak; it will be excreted by liver metabolism, with the urine. Analgesic effects on inflammatory pain there, and its mechanism of inhibiting prostaglandin synthesis. Salicylic acid is mainly used on the efficacy of drugs difficult to tolerate, or not significant rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and so on. Can also be used for acute gout and cancer, fever, or other difficult to control fever.

Specification:

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries. 

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis. 

With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry. 

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.