Chinese Manufacturer Supply Top Purity 65666-07-1 with Lowest Price Silymarin CAS NO.65666-07-1

FOB Price: USD: 800.00-1,000.00 /Metric Ton Get Latest Price
Min.Order: 1 Kilogram
Payment Terms: D/A,D/P,T/T,
Available Specifications:
99%(1-100)Metric Ton1000/Metric Ton1USD99%(101-200)Metric Ton800/Metric Ton101USD

Product Details

Keywords

Silymarin
65666-07-1 competitive price
Silymarin 98%MIN

Quick Details

ProName: Silymarin 98%MIN 65666-07-1 competitiv...
CasNo: 65666-07-1
Molecular Formula: C25H22O10
Appearance: Solid powder
Application: Applied in dietary supplements,pharmac...
DeliveryTime: Prompt after order confirmation
PackAge: Foil bag or drum
Port: Beijing or Guangzhou Port
ProductionCapacity: 5000 Metric Ton/Day
Purity: 99% BY HPLC
Storage: Sealed,light and oxygen resistant
Transportation: by sea or air
LimitNum: 1 Kilogram
Grade: Industrial Grade,Food Grade,Reagent Gr...

Superiority

Silymarin 98%MIN 65666-07-1 competitive price

Superiority

pioneerbiotech is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals.

We could give you:
1.Best quality in your requirement
2.Competitive price in China market
3.mature Technical support
4.Professional logistic support
All we want is win-win business. Send yr. inquiries, you will get it!

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

Annually, more than 3,000 tons of a wide range of herbal extracts and natural active substances are extracted at the Kono Chem Co.,Ltd manufacturing plant near Xi'an, China. These extracts are in compliance with worldwide GMP、HACCP norms, international Pharmacopoeias, and international regulations.
The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Kono Chem. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

With our phytopharmaceutical background and knowledge through experience, Kono Chem can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.

Process Capability : Suoer critical CO2 extraction method Fermentation expert Other synthesis service

After-sale Service : Prompt delivery in worldwide 24 hour online Goods return policy

Details

Process Capability : Suoer critical CO2 extraction method Fermentation expert Other synthesis service

After-sale Service : Prompt delivery in worldwide 24 hour online Goods return policy

Specifications

1.Active ingredients:Silymarin
2.Specification:Silymarin 80%UV
Silymarin 80%HPLC
3.Free sample
5.Color:Light yellow powder

Milk Thistle Extract

Detailed Product Description

1.Milk Thistle Extract
2.80% Silymarin UV, 30% Silybin HPLC
3.Brown yellow powder
4.Free Sample is available
5. GMP,Kosher

Profile

Plant source: Milk Thistle

Latin Name: Silybum marianum. (L.)Gaertner

Part of used: Seed

Appearance : Brown yellow powder

Active Ingredient: Silymarin

Specification: 80% Silymarin UV, 30% Silybin HPLC

Standard: GMP,Kosher,HALAL,ISO9001,HACCP.

Free Sample is available /Unconditional refund if unqualified

Introduction

Silymarin milk thistle,a plant that belongs to the sunflower family, has ancient origins in the Mediterranean.

It was initially used for liver problems and as an antidote for mushroom poisoning throughout Europe.

Chinese Manufacturer Supply Top Purity 65666-07-1 with Lowest Price

Molecular Formula:C25H22O10
Molecular Weight:482.4362
Appearance/Colour:powder
Vapor Pressure:1.63E-26mmHg at 25°C
Melting Point:158 °C
Refractive Index:1.684
Boiling Point:793 °C at 760 mmHg
Flash Point:274.4 °C
PSA：155.14000
Density:1.527 g/cm³
LogP:2.36270

Silymarin(Cas 65666-07-1) Usage

Pharmacokinetics	Silymarin is insoluble in water and is often administered in a capsulated form. It is absorbed orally, with peak plasma concentration in 6-8 hr. But, the oral absorption of silymarin is only about 23-47% leading to low bioavailability. The poor water solubility and bioavailability led to the development of enhanced formulations like silipide (Siliphos) a complex of silymarin and phosphatidylcholine which is ten times more bioavailable.
Mechanism of action	Silymarin's hepatoprotective effects are accomplished by several mechanisms which include antioxidant, inhibition of lipid peroxidation, enhanced hepatocyte regeneration, enhanced liver detoxification and protection from glutathione depletion, antiinlammatory effects including inhibition of leukotriene, prostaglandin synthesis and kupffer cells, mast cell stabilization. slowing of fibrosis by reducing conversion of hepatic stellate cells. Silymarin is a naturally-occurring polyphenolic flavonoid compound. Silymarin is derived from the seeds of the milk thistle plant. It has inhibitory effects on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. In one study (Choo et al., 2009), silymarin was shown to significantly prevent melanin production in a dose-dependent manner with an IC50 value of 28.2 μg/ml, without effects on cell viability (Choo et al., 2009). Also, silymarin inhibits the L-DOPA oxidation activity of the rate-limiting melanogenic enzyme tyrosinase in cell based-systems but it does not directly affect cell-free tyrosinase activity (Choo et al., 2009). Furthermore, silymarin decreases the expression of tyrosinase protein (Choo et al., 2009).
Side effects	Silymarin has very low toxicity and has been shown a good safety profile. At high doses it has a laxative effect due to increased bile secretion, adverse effects related to GI tract were reported in 2-10% patients in a clinical trial.
Indications	Milk thistle (Silybum [Carduus] marianus) is a spiny European plant with white-veined leaves and milky sap, the seed of which is used to treat liver disease.Milk thistle seed extract is used orally in the treatment of alcoholic and other cirrhoses and in Europe intravenously for its hepatoprotective effect in Amanita and other mushroom poisonings. It is grown in this country primarily as a “liver cleanser” and is reputed to protect this organ from a wide array of toxins.Milk thistle seed contains the active principle silymarin, a complex of flavonolignan compounds including silibinin (silybin), silidianin, and silychristin.
Biochem/physiol Actions	Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin.
Toxicity evaluation	Silymarin has been known for its very low toxicity, Acute toxicity studies of silymarin after intravenous infusion have been carried out in mice, rats, rabbits and dogs. The LD50 values were 400 mg/kg in mice, 385 mg/ kg in rats, and 140 mg/kg in rabbits and dogs though these values were dependent on infusion rate. With slow infusion rate (over 2 to 3 h) the LD50 increased to 2 g/kg in rats and after oral administration it was even 10 g/kg.
Physical properties	Silymarin is obtained from silybum marianum (milk thistle), an edible plant that has been used medicinally for centuries as a herbal medicine for the treatment of liver related disorders. The plant is native to the Mediterranean andis widely found in Europe and North America. It also grows in India, China, South America and Australia. This herb is approved for sale in Canada in different products and gains an annual business of 180 million in Germany. Silymarin is a polyphenolic flavonoid, extracted using 95% ethanol, from the seeds of the milk thistle. The plant consists of approximately 70-80% of silymarin flavonolignans and approximately 20-30% undefined fraction. The most prevalent component is Silybin (50-60% of Silymarin). It consists of seven flavonoglignans (silibinin, isosilibinin, silychristin, isosilychristin and silydianin) and a flavonoid (taxifolin).
General Description	Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.

InChI:InChI=1/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23-,24-,25+/m0/s1