manufacturer of 70-18-8 Glutathione 70-18-8 70-18-8 wholesale CAS NO.70-18-8

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70-18-8 wholesale
Glutathione 70-18-8
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ProName: manufacturer of 70-18-8 Glutathione 70...
CasNo: 70-18-8
Molecular Formula: C10H17N3O6S
Appearance: White powder
Application: 1.Food spplements2.Cosmetics
DeliveryTime: 3 working days
PackAge: aluminum foil bag or drum
Port: Guangzhou
ProductionCapacity: 5000 Metric Ton/Day
Purity: 99%
Storage: under room temperature
Transportation: By sea or by air courier
LimitNum: 1 Kilogram
Moisture Content: 1
Residual Solvent: 1
Heavy Metal: 1
Grade: Pharma Grade

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manufacturer of 70-18-8 Glutathione 70-18-8 70-18-8 wholesale

Superiority

pioneerbiotech is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals.

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Glutathione Usage And Synthesis

Features and functions	Glutathione is composed of glutamic acid, cysteine and glycine by peptide bonds condensation of three peptide compounds,which is the most important antioxidant stress of low molecular mercaptan in mammalian cells.We discovered it in 1921 and determined the chemical structure in 1930 , the famous American nutrition health experts said Dr Al sensitive del glutathione is three times the efficiency of the anti-aging amino acid, also known as the antioxidant master of nature, the appearance is colorless transparent thin granular crystal, it is soluble in water, dilute alcohol, liquid ammonia, dimethyl formamide,and it’s insoluble in ethanol, ether, acetone.Its solid character is stable, its aqueous solution is easy oxidized in the air for oxidized glutathione, widely exists in baker's yeast, wheat germ, animal liver, chicken blood, pig blood, tomato, pineapple, cucumber, of which is highest in the wheat germ and liver, content as high as 100 ~ 1000 mg / 100 g.With antioxidant, scavenging free radicals, detoxification, enhance immunity, anti-aging, anti-cancer, anti radiation damage, and other functions.It also helps white blood cells to kill bacteria and prevent the oxidation of the vitamins C and E, to prevent stroke and cataract formation.In addition, glutathione can bind the carcinogen, than excrete them through the urine in vitro. The liver is the most important detoxification organs, which contains rich in glutathione (GSH) on the liver function such as synthesis, detoxification, estrogen inactivated protection.It is the first anti - oxidant that the human body is to counteract the damage of free radicals, and the free radical is a contributing factor to the aging and disease.When the liver is damage, such as suffering from all kinds of liver disease, the body will consume large amounts of GSH to help repair the injured liver and detoxification, that cause the body's glutathione are greatly reduced.But this time we need to take some glutathione peptide drugs, is advantageous to the injury of liver to repair itself.Thus, glutathione peptide drugs are suitable for viral hepatitis (hepatitis a and hepatitis b, etc.), alcoholic liver disease,drug-induced liver disease, fatty liver disease ,it’s a good medicine to protect liver.
Three active peptide compound	Glutathione (Glutathione, GSH) is made up of glutamic acid, cysteine and glycine by peptide bonds condensation of three peptide compounds, chemical name called gamma - L - glutamine - L - in ammonia acyl - glycine, its structural formula is shown in figure 1. Structured from the figure, the GSH and other peptide and protein is different, it's a special peptide bond in the molecule,by glutamate gamma carboxyl (- COOH) and alpha amino - cysteine (NH2) peptidebond condensation. Figure 1 :Glutathione (GSH) chemical structural formula GSH biosynthesis is directly controlled by its synthetase, rather than as protein synthesis is conducted on the ribosome, glutathione biosynthesis includes the following two reaction, as shown in figure 2. Figure 2: The synthesis of GSH Hopkins first discovered glutathione as early as 1921 , than divided it into reduced glutathione (GSH) and oxidative type (GSSG) two kinds.GSH exists in all living cells, it’s higher in yeast, wheat germ and liver, 100 ~ 1000 mg / 100 g.According to recent data, S.c erevisiae Jacqueline Nottingham - 5-8 strains of GSH content of up to 3058 mg / 3058 g.In dry yeast type oxidation GSH exists, and almost all people in red blood cells were reduced glutathione, GSH can be synthesized in the red blood cells.Glutathione molecule contains a lively mercapto - SH, susceptible to oxidative dehydrogenation, two molecules of reduced glutathione (GSH) into a molecular dehydrogenation oxidation type glutathione (GSSG).Peptide by oxidation type in two three disulfide bond together, which play an important physiological role in living organisms is reduced glutathione, GSSG as GSH is physiological activity.
The physical and chemical properties	Glutathione molecular weight of 307.33, melting point of 189 ~ 193 ℃ (decomposition), crystal is colorless transparent thin cylindrical in shape and isoelectric point of 5.93.It is soluble in water, dilute alcohol, liquid ammonia and methyl formamide, and insoluble in alcohol, ether and acetone.Organisms only with physiological activity, GSH and GSSG need to restore to play its important physiological functions.The GSH under high water activity is not easy to save, only controlling the water activity below 0.3 to long-term stability.Studies have found that in vitamin C (pH3.3) in aqueous solution containing GSH, with strong reducing effect of vitamin C, GSH no oxidation of solution for the GSSG, but the decomposition speed is accelerated;But in the vitamin C solution GSSG will not change as GSH, and save the stability is very good.And oral intake of GSSG in the upper small intestine can be restored as GSH, in the small intestine epithelial cell surface by gamma GTP (GSH is decomposed into glutamic acid and Cys - Gly) and the role of the dipeptide enzyme and is absorbed, can also play an important physiological function. Glutathione is widely found in animals and plants, and the contents of the bread yeast, wheat germ and animal liver are very high,100 ~ 100 mg / 1000 g;Content is also rich in human and animal blood, such as human blood contains 26 ~ 34 mg / 100 g, chicken blood contains 58-73 mg / 73 g, pig blood contains 10 ~ 15 mg / 100 g, the dog blood contains 14 ~ 22 mg / 100 g.Many vegetables, potato and corn also contains GSH (see table 1). The above information is edited bytongtong of Chemicalbook.
Food additives	1. join the flour products, can play a role of reduction.Not only make the time of making bread reduced to half of the original or a third, labor conditions greatly improved, and a food nutrition reinforcement and other functions. 2. it added to the yogurt and infant foods, the equivalent of vitamin C, can have the effect of stabilizing agent. 3.to the fish cake, it can prevent the color deepened. 4.added to foods such as meat and cheese, with strong flavor of effect.
Foods rich in glutathione	Onions, garlic, tomato, fish, shrimp, lamb, peppers.

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L-Glutathione(GSH)
1.the largest L-Glutathione manufacturer in China
2. the L-Glutathione confirm JP XV
3. flexiblea packing

L-Glutathione(GSH)

L-Glutathione Reduced is a tripeptide which consists of glutamic acid, cysteine, and glycin.

1) GSH’s effect on hepatic diseases: it can treat virus hepatitis, alcoholic liver disease, NAFLD, hepatocirrhosis, and DILI, etc.
2) Renal diseases;
3) Protective action to drug-included renal and hepatitis
4) Acute pancreatitis systemic inflammatory response syndrome;
5) Cure diabetes mellitus and DPN;
6) Adjuvant drug in antineoplaston;
7) GSH cures age-related eye diseases;
8) GSH’s protection to intestinal trace;
9) GSH cures anaphylactoid purpura;
10) Treatment to neonatal HIE;
11) Sharing with anticancer drugs: recently, it arouses increasing concern from clinical experts to restrain the side effects of anticancer drugs and strengthen curative effect and host resistance in combination of anticancer drugs;
12) Detoxication: GSH has detoxication to intoxication of medicine, food, heavy metal and carbon monoxide;
13) Anti-ageing

Glutathione Basic information

Features and functions Three active peptide compound The physical and chemical properties Food additives Foods rich in glutathione Reduced glutathione Antidote Antiallergic agent Protect liver agent GSH depletion Antioxidants The preparation of GSH Uses

Product Name:	Glutathione
Synonyms:	REDUCED GLUTATHIONE;copren;deltathione;Glutathion;glutathionesh;glutatiol;glutatione;glutide
CAS:	70-18-8
MF:	C20H32N6O12S2
MW:	612.63
EINECS:	200-725-4
Product Categories:	pharmacetical;Amino Acids 13C, 2H, 15N;Antioxidant;Biochemistry;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Material;Pharmaceutical intermediates;Inhibitors;pharmaceutical
Mol File:	70-18-8.mol

Glutathione Chemical Properties

Melting point	192-195 °C (dec.)(lit.)
alpha	-16.5 º (c=2, H2O)
refractive index	-17 ° (C=2, H2O)
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL
form	powder
Water Solubility	soluble
Merck	14,4475
BRN	1729812
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	70-18-8(CAS DataBase Reference)
EPA Substance Registry System	Glycine, L-.gamma.-glutamyl-L-cysteinyl- (70-18-8)