From the very beginning, we strictly manage our production according to the demand of ISO9000、ISO14001, now has received the recogonition from costomers all over the world and has passed the audit by authoritative labs. At present, our products are mainly related to biopharmaceuticals, flavors, intermediates of pesticides, veterinary drugs development, as well as some custom synthesis.
Thanks to our EHS management system and high quality control, now 85% of our products are well-selling and appreciated in almost 50 countries all over the world, and established long-term cooperative business relationship with multinational companies such as CIPLA、BIOCON、DSM.

Hydroxypropyl methyl cellulose Basic information

Product features Usage method Ophthalmic remedy Identification test Toxicity Limited use Chemical property Uses Methods of production

Product Name:	Hydroxypropyl methyl cellulose
Synonyms:	MODIFIED CELLULOSE;PROPYLENE GLYCOL ETHER OF METHYLCELLULOSE;HPMC;HYPOMELLOSE 2208;HYPOMELLOSE 2906;HYPOMELLOSE 2910;HYPROMELLOSE;HYPROMELLOSE, 2208
CAS:	9004-65-3
MF:	C3H7O *
MW:	59.08708
EINECS:	220-971-6
Product Categories:	Natural Polymers;Cellulose;Polymer Science;Carbohydrates H-LBiochemicals and Reagents;Carbohydrates;Carbohydrates A to;Polysaccharide;Dynamic Sieving;Capillary Electrophoresis;Protein Electrophoresis;Biochemicals and Reagents;Oligosaccharide;A to Z Books and Software Titles;Biotechnology booksBooks and Software;Books and Software;C;Labware;Capillary Zone Electrophoresis;Materials Science;Natural Polymers;Polymer Science;Polymers;Other APIs;propylene glycol ether;Thickening agent;pharmeceutical raw material or intermediates;thickener ,binders;Imidazoles ,Homopiperidines
Mol File:	9004-65-3.mol

Hydroxypropyl methyl cellulose Usage And Synthesis

Product features	Hydroxypropyl methyl cellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.It is white or pale white cellulose powder or particles. The characteristics of cold water dissolution and hot water insoluble are similar with methyl cellulose. Solubility in organic solvents is superior than water soluble, can be dissolved in anhydrous methanol and ethanol solution, also soluble in chlorinated hydrocarbons and ketones in organic solvents. Soluble in water, its water solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the reversible conversion of sol to gel. Can be used alone in the cold drink, also can be used with other emulsifier, stabilizer. To cold drink, the maximum amount is 1%. Hydroxypropyl methyl cellulose and other water-soluble high weight compounds use mixture, become transparent, higher viscosity. The gelation temperature of low viscosity products is higher than high viscosity of products. Its solution is stable at room temperature. In recent years, It has been widely used in petroleum chemical industry, papermaking, leather, textile printing and dyeing, pharmaceutical, food, cosmetics and other industries, and as the dispersing agent, thickening agent, adhesive, excipient, capsule, oil resistant coating and packing etc. Figure 1 The molecular structure of hydroxypropyl methyl cellulose
Usage method	Purpose: thickener, emulsifier, stabilizer.  1 note: hydroxypropyl methyl cellulose has many excellent properties. It can be used for baking food, pasty food, enriched food, milk paste mixing drinks, pie fillings, toppings, salad and fast food. The use of its thermal gel properties can make deep fried food, not only can save a lot of oil, but also the product has a unique taste of the soft. The use of its acid, alkali stability, anti-enzymes, do not participate in metabolism, enhance the characteristics of gastrointestinal motility, but also used to produce a variety of health food. 2 usage range and usage (1) The provisions on the use of hygienic standards for food additives (GB 2760-1996) shall be used in all kinds of food appropriately. (2) The actual use of reference: the use of high transparency film and film of this product can be used in the manufacture of casings, dosage is 5%. It is used as a thickener mayonnaise (HPMC-60RT400), dosage of 0.5%~2%.
Ophthalmic remedy	[Application] Through the stability and thickening of anterior corneal tear, it can promote corneal moist, cut off time, extend the tear film in dry eyes and can prolong the retention time of tear film. It used for the lack of clinical tear caused by dry eyes and eye irritation, and the treatment of keratoconjunctivitis sicca, exposure keratitis and Neuroparalytic keratitis to prevent corneal injury. It can be used for hard contact lenses or artificial eye lubricant. For gonioscopy, contact endoscopy and surgery, it is as a medium in condensation genioplasty or retinal laser iridectomy in the process to protect the cornea.  [dosage] eye: 0.3%~1% solution, 1 drops, 3~4 times /d. 2% of the solution is used for the anterior chamber angle. [Attention and taboo] Using it can sometimes have blurred vision or eyelid adhesion feeling. Continuous time should not exceed 3 Days. Wearing soft contact lens is banned to corneal epithelial disease. Wear a hard contact lens should prevent the lens floating. [Specification] eye drops: 0.3%, 0.5%, 1%, 2.5%. This information is edited by Chemicalbook Xiannan (2015-08-31).
Identification test	It is soluble in water swelling, forming a transparent milky white sticky gel solution, and insoluble in ethanol.
Toxicity	ADI does not make special provisions (FAO/WHO, 2001). It can be used for food safety (FDA. §172.87, 2000). LD505200mg/kg (rats, intra peritoneal injection).
Limited use	FAO/WHO (1984): Cold drink ,10g/kg (in the end product design, single use or with other emulsifier, stabilizer and thickener dosage).  GB 2760-96: all kinds of food, to GMP limited.
Chemical property	Hydroxypropyl methyl cellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.It is white or pale white cellulose powder or particles.It has different types of products, the methoxy and hydroxypropyl content ratio is different. It is white or gray fibrous powder or particles. It is soluble in water and some organic solvents and unsoluble in ethanol. Aqueous solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the sol to gel reversible transformation.
Uses	1. Thickener, stabilizer, emulsifier, emulsifier, suspending agent.  2. It is used as a synthetic resin dispersing agent, and the coating agent,also used as a thickener. 3. This product is used as a thickener, dispersant, binder, emulsifier and stabilizer in the textile industry. It is also widely used in synthetic resin, petrochemical, ceramics, paper, leather, medicine, food, cosmetics and other industries. 4. Used in synthetic resin, petroleum chemical industry, ceramics, paper, leather, textile, medicine, food, cosmetics and other daily chemicals and as dispersing agent, thickening agent, binders, excipients, capsules, oil resistant coating and packing etc.
Methods of production	1.The refined cotton cellulose with alkali treatment at 35-40 ℃ for half an hour, press, crushed the cellulose, aging at 35 ℃, so that the average degree of polymerization of alkali cellulose is in a desired range. The alkali fiber into etherification reactor, followed by adding epoxy propane and methane chloride, etherification at 50-80 ℃ for 5h, the maximum pressure is about 1.8MPa. The reaction products were produced by postprocessing (hydrochloric acid and oxalic acid, washing and drying). The consumption of raw material of cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, solid alkali 1200kg/t, hydrochloride 30kg/t, oxalic acid 50kg/t. 2.100 kg refined cotton linters immersed in 45% solution, temperature is 35 to 40℃, time is 0.5 to 1 h, and then remove the press. The pressure to weight is 2.7 times as the weight of lint, stop pressure. Carry out the crushing. At 35℃, aging for 16h. In the reaction kettle, the chlorinated methane, propylene oxide were added into the reaction kettle. At 80℃, the pressure was 1.8 MPa, the reaction time is 5 to 8 h, and the amount of hydrochloric acid and oxalic acid were added to the hot water at 90℃. Dewatering with centrifuge, washing to neutral, when the water content of the material is below to 60% , 130℃ of hot air flow dried to the moisture content is below 5%. Finally, the finished product sieved by 20 mesh. 3. Prepared by cellulose, methyl chloride, and ethylene oxide.
Chemical Properties	white or slightly beige powder or a viscous solution
Uses	Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.
Uses	A thickener for aqueous and non-aqueous systems.

About us 

Kono Chem., Ltd was established in 2014, which is surbordinated to PIONEER BIOTECH HongKong, and has got great support from the State Department of Commerce as one of the most promising export-oriented manufacturing enterprises.

Kono Chem is headquarted in Xi’ an Shaanxi Province, China, with convenient transportation access, covering an area of 312, 000 square meters, and technicians accounted for 35% of the total employees. Presently, we have two chemical fermentation plant, one test reaction plant, and one Provincial Research and Development Center now. Our well-equipped facilities and excellent quality control throughout production enables us to guarantee customer satisfaction.

From the very beginning, we strictly manage our production according to the demand of ISO9000、ISO14001, now has received the recogonition from costomers all over the world and has passed the audit by authoritative labs. At present, our products are mainly related to biopharmaceuticals, flavors, intermediates of pesticides, veterinary drugs development, as well as some custom synthesis.
Thanks to our EHS management system and high quality control, now 85% of our products are well-selling and appreciated in almost 50 countries all over the world, and established long-term cooperative business relationship with multinational companies such as CIPLA、BIOCON、DSM.
Persisting to the principle of “Integrity and diligence”, we are rising up with hardworking employees and efficient rearch and development system. We are engaging to play an active role in the development of chemical industry together with you!