Xi'an Kono Chem Co., Ltd., founded in 2014, is a holding enterprise of Hongkong Pioneer Biotech Group. It is an export-oriented manufacturing enterprise supported by the Ministry of Commerce. 

Kono Chem is located in Xi'an, Shaanxi Province, equipped with a number of engineers in pharmaceutical, nutrition, bioengineerting, commited themselves to create products that meeet customers' requirements. At present, Kono's main products cover pharmaceutical, food, cosmetics, scientific research. 

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1. Introduction 

Superoxide dismutase (SOD) is a class of metalloenzymes widely distributed in tissue cells with strong oxidizing properties and scavenging free radical metal ions. As a cleaning agent for superoxide anion free radicals in living organisms, it exists widely in various animals, plants and microorganisms, and is an important antioxidant, it protects cells exposed to oxygen. SOD powder mainly has three types: Cu/ZnSOD, Mn-SOD; Fe-SOD.

2. Functions

2.1 Remove free radicals, improve immunity, improve sleep, enhance memory, and delay aging

It can quickly catalyze the disproportionation reaction of free radicals in the human body. When it encounters harmful free radicals, it promotes the decomposition of superoxide radicals, turning it into water molecules and oxygen molecules that are harmless to the human body, and eliminates lipid peroxidation in tissue cells. The protective part is beneficial to life substances and physiological functions. Free radicals (such as nitric oxide) maintain the balance of free radicals in the body, deeply regulate sleep quality, enhance memory, improve the body's immunity, resist diseases, stimulate youthful vitality, and delay aging.

2.2 Effectively reduce blood lipids, blood pressure, cholesterol, blood viscosity, and help prevent senile dementia

When the SOD content in the human body gradually decreases, free radicals are continuously generated, and cross-linking reactions occur with proteins in the blood vessel wall, which thickens and hardens the arterial wall and narrows the lumen. Cerebrovascular disease. SOD enters the blood to scavenge the deposited free radicals, so that the deposited lipoproteins become free again, rapidly increase the utilization rate of oxygen, improve peripheral blood flow, and reduce myocardial lipofuscin.

2.3 Enhance liver and gallbladder function

The lipid peroxidation of oxygen free radicals on biological membranes causes damage to liver cell membranes, leading to degeneration and necrosis of liver cells, damage to liver tissue structure, and liver damage. SOD can reduce the level of toxins in the blood, prevent hepatic coma, reduce blood ammonia, reduce the burden on the liver, and improve liver function.

2.4 Prevent senile cataract and improve vision

Excessive production of reactive oxygen radicals in the eye can cause changes in intraocular proteins, especially the cross-linking and denaturation of A-crystallin and B-crystallin, and at the same time, the lens plasma membrane can be peroxidized to form insoluble polymer products. Aggregated in the middle of the lens, various enzymes are therefore inactive, leading to the formation of cataracts. Supplementing with SOD can prevent cataract formation and improve vision.

2.5 Recovery effect on diabetes

Diabetes mellitus is a common endocrine and metabolic disease with genetic predisposition, and its basic pathology is the metabolic disorder of sugar, fat and protein caused by absolute or relative insufficient insulin secretion. The SOD content of patients was significantly decreased, and the plasma lipid peroxide and hydrogen peroxide were significantly increased. Cardiovascular, eye, kidney, nerve and other diseases were common after prolonged illness. Therefore, when SOD is supplemented during treatment, the islet cells manipulated by free radicals begin to rejuvenate and divide into new islet cells, and insulin secretion also becomes vigorous. It plays an important role in preventing complications and protecting islet B cells from secreting insulin.

2.6 Regulate female menstrual cycle and prevent male prostatitis

SOD powder has strong antioxidant capacity and can inhibit the synthesis and release of prostaglandins and leukotrienes and other inflammatory factors. SOD can inhibit the release of PGE2 of prostaglandins to improve prostate inflammation, activate the activity of lysosomes in prostatic hyperplasia tissue cells, and shrink the hyperplasia tissue cells, so that the prostate is in a truly healthy state, and its functions can be replayed. The operation of the two major systems is restored, making it possible to achieve normal urination, and at the same time physiologically regulate and repair the gonads oxidized by free radicals, improve the activity of renal dynamic enzymes, and achieve the purpose of sexual function and physiological cycle recovery.

2.7 Good skin care efficacy

A large number of studies have proved that SOD has obvious anti-aging, anti-radiation and anti-inflammatory effects. Therefore, using SOD for skin care can delay skin aging, fade or lighten dark spots, and has anti-wrinkle and whitening effects. It can promote the formation of moderate cross-linking of collagen, as an effective free radical scavenger, prevent the appearance of skin wrinkles and vesicles, keep the skin supple and smooth; stabilize collagen and hard proteins, improve skin elasticity, and achieve anti-aging effects . Oxygen free radicals can act on unsaturated fatty acids in the body, resulting in unstable spots and pigmentation. Supplementing exogenous SOD to the body through appropriate channels can effectively remove freckles, lighten freckles, and resist aging. In addition, SOD has a certain absorption effect on ultraviolet light with wavelengths of 258-268nm and 270-320nm, which makes SOD cosmetics a better sunscreen product. And SOD can help protect the skin from UV damage.

3. Applications

In recent years, SOD powder has made substantial progress in both basic and applied research, mainly manifested in a wide range of applications in medical clinics, food industry, and cosmetics.

4. Flow Chart

Plant raw material→mashing and homogenizing→pressing and filtering→adding ethanol→centrifuging→adding acetone→centrifuging→dissolving the precipitate in phosphate buffer→dialysis→filtering→collecting the active fraction→refine→finished product 

5. Quality Standard

6. Method of Analysis

MOA is available upon request.